Carnegie Mellon University biologists are the first to show that minor changes in the tail of one protein cripple yeasts ability to assemble protein-making machines called ribosomes. The findings, published in a recent issue of Molecular Cell, ultimately could help scientists develop better drugs to fight fungal infections.
"Our findings are the first to link the structure of a ribosomal protein to a critical step in the pathway to assembling a fully functional ribosome," explained John Woolford, professor of biological sciences at the Mellon College of Science at Carnegie Mellon. "Understanding the molecular basis of ribosome assembly offers a rational scheme for designing drugs to interfere with that process."
A complex of protein and ribonucleic acid (RNA), ribosomes are present in vast quantities inside every cell. There, they translate genetic information into proteins that control many activities, including cell movement, metabolism, division and response to the environment. Because ribosomes are essential for protein production, problems with their assembly inevitably spell cell death.
Lauren Ward | EurekAlert!
Molecular doorstop could be key to new tuberculosis drugs
20.03.2018 | Rockefeller University
Modified biomaterials self-assemble on temperature cues
20.03.2018 | Duke University
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
20.03.2018 | Agricultural and Forestry Science
20.03.2018 | Life Sciences
20.03.2018 | Life Sciences