Brown University researchers have found that there are multiple independent ways to stop cell division, a phenomenon that prevents the spread of genetic mutation, which can make cells cancerous. Results of this research, along with an accompanying editorial, were published in the current issue of the journal Molecular Cell.
The findings will be of interest to scientists who are developing new-generation drugs that target cancer at the molecular level, according to John Sedivy, principal investigator of the study and a professor in the Department of Molecular Biology, Cell Biology and Biochemistry.
“If you can trip a senescence pathway,” Sedivy said, “you’d have a pretty terrific drug.”
Wendy Lawton | Brown University
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