Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New insight into how tumors resist radiation

18.05.2004


Scientists have uncovered new evidence about a critical cellular pathway that makes tumor blood vessels resistant to radiation therapy. The research, published in the May issue of Cancer Cell, may have significant clinical applications, as a better understanding of this mechanism may open new avenues for enhancing the effectiveness of radiation therapy.



Tumor growth and survival is completely dependant upon having an adequate blood supply. In fact, the sensitivity of a tumor’s blood vessels to radiation therapy is a major determinant of how successful the treatment will be. Recent studies have shown, however, that tumors can respond to radiation by secreting factors that promote the survival of blood vessel cells. Dr. Mark W. Dewhirst and colleagues from Duke University Medical Center have investigated the activation of this protective response and whether the process can be successfully inhibited, thereby maximizing the effectiveness of radiation therapy. The investigators focused on a molecule called hypoxia inducible factor-1 (HIF-1) that is known to stimulate the production of factors called cytokines that are related to tumor metabolism, growth, and blood vessel formation.

They found that HIF-1 levels were increased in tumors after radiation treatment, and that HIF-1-regulated cytokines decreased the sensitivity of blood vessels to radiation. Based on this knowledge, the investigators demonstrated that administration of low doses of a HIF-1 inhibitor in tumor-bearing mice dramatically enhanced the effectiveness of radiation therapy by destroying tumor blood vessels without having an impact on normal vessels.


These results indicate that HIF-1 acts as a major factor directing resistance of tumor vasculature to radiation therapy. According to Dr. Dewhirst, "We believe that by understanding how this protective response is activated, we can discover an effective means of inhibiting it.

This work takes a major step toward achieving this understanding and might eventually translate into a significant clinical benefit by allowing optimal sensitization of tumor vasculature to conventional therapies including radiation."


Benjamin J. Moeller, Yiting Cao, Chuan Y. Li, and Mark W. Dewhirst: "Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules"

Published in Cancer Cell, Volume 5, Number 5, May 2004, pages 429-441.

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com/

More articles from Life Sciences:

nachricht Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel

nachricht The Nagoya Protocol Creates Disadvantages for Many Countries when Applied to Microorganisms
05.12.2016 | Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

IHP presents the fastest silicon-based transistor in the world

05.12.2016 | Power and Electrical Engineering

InLight study: insights into chemical processes using light

05.12.2016 | Materials Sciences

High-precision magnetic field sensing

05.12.2016 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>