Scientists identify a key mechanism to recognize misfolded proteins
Scientists at McGill Universitys Faculty of Medicine have discovered a key step that will provide new targets for treatments of many degenerative diseases such as Alzheimers, Cystic Fibrosis and Diabetes. Dr. David Thomas, Chair of Biochemistry, Dr. John Bergeron, Chair of Anatomy and Cell Biology and colleagues have identified a mechanism by which misfolded proteins are recognized in the cell. This is a critical process as proteins that are not correctly folded or shaped are extremely harmful to cells and are the basis for a number of human degenerative diseases. The findings were published in the prestigious journal Nature Structural and Molecular Biology.
"We have identified a central enzyme that is sensitive to very subtle changes in the folded state of a protein," explained Dr. David Thomas. "Proteins are the building blocks and machines of our bodies. In order for them to work correctly they have to fit together. Cells in our bodies have developed quality control mechanisms to assure proper folding. When something goes wrong, cells can accumulate misfolded proteins that dont work properly. The misfolding of proteins is the basis for a number of neurodegenerative diseases such as Alzheimers and Parkinsons. Our findings are an important step toward the development of innovative prevention and treatment strategies for such diseases."
Sandra McPherson | McGill University
Nesting aids make agricultural fields attractive for bees
20.07.2017 | Julius-Maximilians-Universität Würzburg
The Kitchen Sponge – Breeding Ground for Germs
20.07.2017 | Hochschule Furtwangen
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
19.07.2017 | Event News
12.07.2017 | Event News
12.07.2017 | Event News
20.07.2017 | Information Technology
20.07.2017 | Materials Sciences
20.07.2017 | Physics and Astronomy