Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Annotation marathon validates 21,037 human genes

20.04.2004


International consortium provides the first step towards a comprehensive functional link between the genome sequence scaffold and human diseases



The announcement of the human genome sequence three years ago was widely hailed as one of the great scientific achievements in modern history. But sequencing the genome is just a first step -- the monumental task of ascribing biological meaning to those sequences has just begun. The H-Invitational international consortium, led by Takashi Gojobori (Tokyo, Japan) has taken a significant step towards this goal, by validating and annotating over 20,000 human genes, using publicly available resources.

By relating intermediate gene products called messenger RNAs to each of their parent genes, and exhaustively connecting them to the relevant proteins, the consortium has established a reliable systematic network of human-curated relationships between genes and their biological functions.


The study, reported in the open access journal PLoS Biology, has taken over two years to complete, and is expected to set the standard for analysis of gene expression and human diseases worldwide through the publicly available H-Invitational database. There are estimated to be about 30,000 genes in humans, so having a detailed functional map of a majority of them will be a boon for geneticists, drug researchers and genome scientists around the world. There is a wealth of information, including evidence for several thousand new genes, data about variable expression and genetic variation within the genes.

The consortium has laid the groundwork to address the challenge of connecting the functions of genes and their products to the clinical effects that each of them has upon human health. "We are confident now that anyone in academia or industry who uses our database will gain far deeper insight into the meaning of human disease than was previously possible" stated Professor Gojobori. The work also builds on the traditions of international cooperation and large-scale collaboration, which played such an important part in the deciphering of the sequence itself. The consortium is made up of 152 scientists from developed as well as developing nations, including Australia, Brazil, China, France, Germany, Korea, South Africa, Sweden, Switzerland, the United Kingdom and the United States.


Citation: Imanishi T, Itoh T, Suzuki Y, O’Donovan C, Fukuchi S, et al. (2004) Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones. PLoS Biol: e162 DOI: 10.1371/journal.pbio.0020162

CONTACT:
Takashi Gojobori, Ph.D
Director and Professor, Center for Information
Biology and DNA Data Bank of Japan (DDBJ),
National Institute of Genetics, Mishima 411, Japan
Email: tgojobor@genes.nig.ac.jp
Tel: +81-55-981-6847 Fax: +81-55-981-6848
URL: http://www.cib.nig.ac.jp

Hemai Parthasarathy | EurekAlert!
Further information:
http://www.plosbiology.org
http://www.plosbiology.org/plosonline/?request=get-document&doi=10.1371/journal.pbio.0020162
http://ddbj.nig.ac.jp

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Supersensitive through quantum entanglement

28.06.2017 | Physics and Astronomy

X-ray photoelectron spectroscopy under real ambient pressure conditions

28.06.2017 | Physics and Astronomy

Mice provide insight into genetics of autism spectrum disorders

28.06.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>