A team of researchers from the University Hospital of Grenoble (CHU – Inserm U647) and the ESRF1 has found a new treatment that improves the survival of rats with high-grade gliomas.
This research was carried out at the ESRF Medical Beamline. It showed that after a year of this treatment, three rats out of 10 were considered cured, whereas without treatment, all would be dead. The results have just been published in the scientific journal Cancer Research. A glioma is one of the most frequent brain tumours in human adults, and it is not curable. Clinical trials on humans are planned for the near future.
Today, the median survival for patients with glioma is less than a year. Around 5 to 10 adults out of 100.000 suffer from this brain tumour. Traditional radiotherapy using hospital X-rays only has a palliative effect because gliomas are some of the most radio-resistant human tumours. Chemotherapy is ineffective most of the time. Several therapeutic techniques have been developed over the last years using animal models, but none has had such successful results as this new treatment with cis-platinum combined with monochromatic synchrotron x-rays. This new technique combines chemotherapy with radiotherapy in such a way that both techniques are effective when associated.
Montserrat Capellas | alfa
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