Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Clues For Brain Cancer Treatment Found At The ESRF

05.04.2004


A team of researchers from the University Hospital of Grenoble (CHU – Inserm U647) and the ESRF1 has found a new treatment that improves the survival of rats with high-grade gliomas.



This research was carried out at the ESRF Medical Beamline. It showed that after a year of this treatment, three rats out of 10 were considered cured, whereas without treatment, all would be dead. The results have just been published in the scientific journal Cancer Research. A glioma is one of the most frequent brain tumours in human adults, and it is not curable. Clinical trials on humans are planned for the near future.

Today, the median survival for patients with glioma is less than a year. Around 5 to 10 adults out of 100.000 suffer from this brain tumour. Traditional radiotherapy using hospital X-rays only has a palliative effect because gliomas are some of the most radio-resistant human tumours. Chemotherapy is ineffective most of the time. Several therapeutic techniques have been developed over the last years using animal models, but none has had such successful results as this new treatment with cis-platinum combined with monochromatic synchrotron x-rays. This new technique combines chemotherapy with radiotherapy in such a way that both techniques are effective when associated.


In this study, a drug called Cis-platinum was injected into the brain of rats bearing F98 glioma. The substance entered the DNAs of the tumour and limited the tumoral proliferation. A day later, at the Medical Beamline of the ESRF, the tumour was irradiated with X-rays of a very precise energy (monochromatic) The difference between these X-rays and the conventional X-ray sources used in hospitals is the brilliance: the beam produced by the ESRF synchrotron is a hundred thousand times brighter than the beam produced by a hospital X-ray machine, allowing the beam to be tuned at a convenient wavelength.

This in vivo experiment was preceded by in vitro experiments on cells using the same tumoral model (F98). This tumour is extremely radioresistant and it spreads very quickly. The mean survival time of untreated rats was 28 days. If cis-platinum was injected, they survived up to 39 days. If the rats were irradiated with X-rays at a certain wavelength, it could result in a maximum of 48 days of survival. The combination of both treatments, with a specific radiation dose and a specific X-ray wavelength appeared to be the most efficient treatment tested and offered a mean survival time of around 200 days. This means a 6-fold increase in the life span of treated rats compared to those which didn’t receive any treatment.

The success of the trials has led CHU and ESRF researchers to envisage the elaboration of a protocol in order to use these techniques on humans. “There is a lot of technological development to be carried out, but it is feasible”, explains Doctor François Estève, one of the authors of the paper. “The ESRF Medical Beamline is a unique place in the world where pre-clinical and clinical research in radiotherapy with synchrotron radiation is possible nowadays” says Doctor Alberto Bravin, responsible for the Medical Beamline. Rats and humans don’t have so much physical resemblance, so doctors and physicists still cannot say whether they would have the same outstanding results if humans were treated. But François Estève is convinced that “taking into account the impossibility nowadays of healing this brain tumour, it is really a must to try this method”.

Montserrat Capellas | alfa
Further information:
http://www.esrf.fr

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>