When the gene, called Foxm1b, was deleted from liver cells in laboratory mice, the animals failed to develop tumors. Even when the researchers attempted to induce the formation of these tumors artificially, using a standard laboratory technique, the mice remained cancer free.
"To my knowledge, this is the first time a gene has been directly linked to the growth of cancer cells in live animals," said Robert Costa, professor of biochemistry and molecular genetics in the UIC College of Medicine and the lead investigator in the study.
Results of the study are published in todays issue of Genes and Development, the premier peer-reviewed journal on molecular genetics and biology.
BigH1 -- The key histone for male fertility
14.12.2017 | Institute for Research in Biomedicine (IRB Barcelona)
Guardians of the Gate
14.12.2017 | Max-Planck-Institut für Biochemie
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