This x-ray tomography image of a yeast cell taken at the ALS with XM-1 is an example of what could be done with the proposed XM-2. Internal organelles are color-coded according to x-ray absorption. Shown in red are the nucleus (smaller sphere) and large vacuole. Lipid droplets are shown in white, and cytoplasmic structures are shown in either orange or green.
Carolyn Larabell and Mark Le Gros used the current transmission x-ray microscope at the ALS, XM-1, to demonstrate the potential of their new microscopy resource
A first-of-its-kind x-ray microscope being built for the Advanced Light Source (ALS) of the Lawrence Berkeley National Laboratory (Berkeley Lab) holds forth the promise of “cat scans” for biological cells, and other unprecedented capabilities for cell and molecular biology studies. The new microscopy resource also promises a better understanding of human diseases at the molecular level and possibly new discoveries for treating those diseases. Now, researchers with Berkeley Lab and the University of California at San Francisco (UCSF), have received grants from the National Institutes of Health (NIH) and the U.S. Department of Energy (DOE) to build and operate this microscope.
“X-ray microscopy is an emerging new technology that will expand the existing imaging toolbox for cell and molecular biologists, and we would like to make this technology available to the greater biological community,” says cell biologist and microscopy expert Carolyn Larabell, who holds a joint appointment with UCSF’s Anatomy Department, and with Berkeley Lab’s Physical Biosciences Division. She is the principal investigator for this project. Berkeley Lab physicist Mark Le Gros is the co-principal investigator.
“Although there are currently many powerful techniques for imaging biological cells, each with its own unique strengths and limitations, there remains a gap between the information that can be obtained with light microscopy and electron microscopy,” Larabell says. “X-ray microscopy can bridge this gap by combining some of the best features associated with light and electron microscopy, plus bringing in some entirely new capabilities.”
Lynn Yarris | LBNL
Gene therapy shows promise for treating Niemann-Pick disease type C1
27.10.2016 | NIH/National Human Genome Research Institute
'Neighbor maps' reveal the genome's 3-D shape
27.10.2016 | International School of Advanced Studies (SISSA)
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
27.10.2016 | Materials Sciences
27.10.2016 | Physics and Astronomy
27.10.2016 | Life Sciences