This x-ray tomography image of a yeast cell taken at the ALS with XM-1 is an example of what could be done with the proposed XM-2. Internal organelles are color-coded according to x-ray absorption. Shown in red are the nucleus (smaller sphere) and large vacuole. Lipid droplets are shown in white, and cytoplasmic structures are shown in either orange or green.
Carolyn Larabell and Mark Le Gros used the current transmission x-ray microscope at the ALS, XM-1, to demonstrate the potential of their new microscopy resource
A first-of-its-kind x-ray microscope being built for the Advanced Light Source (ALS) of the Lawrence Berkeley National Laboratory (Berkeley Lab) holds forth the promise of “cat scans” for biological cells, and other unprecedented capabilities for cell and molecular biology studies. The new microscopy resource also promises a better understanding of human diseases at the molecular level and possibly new discoveries for treating those diseases. Now, researchers with Berkeley Lab and the University of California at San Francisco (UCSF), have received grants from the National Institutes of Health (NIH) and the U.S. Department of Energy (DOE) to build and operate this microscope.
“X-ray microscopy is an emerging new technology that will expand the existing imaging toolbox for cell and molecular biologists, and we would like to make this technology available to the greater biological community,” says cell biologist and microscopy expert Carolyn Larabell, who holds a joint appointment with UCSF’s Anatomy Department, and with Berkeley Lab’s Physical Biosciences Division. She is the principal investigator for this project. Berkeley Lab physicist Mark Le Gros is the co-principal investigator.
“Although there are currently many powerful techniques for imaging biological cells, each with its own unique strengths and limitations, there remains a gap between the information that can be obtained with light microscopy and electron microscopy,” Larabell says. “X-ray microscopy can bridge this gap by combining some of the best features associated with light and electron microscopy, plus bringing in some entirely new capabilities.”
Lynn Yarris | LBNL
Zap! Graphene is bad news for bacteria
23.05.2017 | Rice University
Discovery of an alga's 'dictionary of genes' could lead to advances in biofuels, medicine
23.05.2017 | University of California - Los Angeles
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
23.05.2017 | Event News
22.05.2017 | Event News
17.05.2017 | Event News
23.05.2017 | Physics and Astronomy
23.05.2017 | Life Sciences
23.05.2017 | Medical Engineering