Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Jefferson Researchers Discover Novel Gene Profile That May Identify Colon Stem Cells

31.03.2004


The findings could potentially lead to a better understanding of the role of stem cells in the development of colon cancer



Researchers at Jefferson Medical College have uncovered a novel pattern of gene expression in the stem cell-rich bottom of tiny “crypts” in the tissue lining the colon. By identifying these patterns, the scientists hope to be able to identify mechanisms through which stem cells contribute to the development of colon cancer.

“Having a genetic signature for the colonic stem cell will give us a tool to investigate the hypothesis that stem cell overpopulation is the key to colon cancer initiation,” says Bruce Boman, M.D., Ph.D., director of the Division of Genetic and Preventive Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia and Jefferson’s Kimmel Cancer Center, who led the work.


Dr. Boman presents his team’s findings March 30 at the annual meeting of the American Association for Cancer Research in Orlando.

According to Dr. Boman, a form of inherited colon cancer, familial adenomatous polyposis, or FAP, may begin when processes that regulate adult stem cells in the colon go awry. To try to understand some of these processes, Dr. Boman and his team decided to first look at the genes expressed in normal colon crypts. The researchers examined sections of the top, middle and bottom of crypts, using microarray technology to analyze which genes are selectively expressed in each region. They were particularly interested in the genes expressed in the bottom of the crypt, where the stem cells reside.

“We’ve found some intriguing patterns of gene expression – patterns that suggest a unique genetic signature for stem cells,” says research technician Moreh Salunek. “We were looking at genes that were unique and up-regulated in the bottom of the crypt, and found that the majority were related to binding processes and catalytic enzymes.” Some were surprising, she says, such as STAMP1, a gene implicated as a marker for the progression of prostate cancer. They also found a gene called HOXD4, which is a developmental gene involved in the formation of the gut.

Stem cells in the normal colon produce daughter cells that proliferate and make their way to the crypt top, where they differentiate into specialized colon cells, says Dr. Boman. Colon cancer is marked by a change in the distribution pattern of proliferating daughter cells.

Next, the researchers plan to use their novel gene profile to investigate cellular changes in colon cancer development. They also plan to use a different microarray to expand the number of genes they can examine.

Steven Benowitz | TJUH
Further information:
http://www.jeffersonhospital.org/news/e3front.dll?durki=17621

More articles from Life Sciences:

nachricht Molecular Force Sensors
20.09.2017 | Max-Planck-Institut für Biochemie

nachricht Foster tadpoles trigger parental instinct in poison frogs
20.09.2017 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

Im Focus: Silencing bacteria

HZI researchers pave the way for new agents that render hospital pathogens mute

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Molecular Force Sensors

20.09.2017 | Life Sciences

Producing electricity during flight

20.09.2017 | Power and Electrical Engineering

Tiny lasers from a gallery of whispers

20.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>