Two studies published in the online issue of Nature report no evidence to suggest that hematopoietic stem cells, which usually produce blood cells, can turn into heart cells after injection into the heart. These studies raise a cautionary note for interpreting the results of ongoing clinical studies in which hematopoietic stem cells are injected into the heart after a heart attack.
Loren Field, Ph.D., professor of medicine and of pediatrics at the Indiana University School of Medicine and senior author of one of the Nature papers says "these studies demonstrate that the stem cells tested do not form new heart muscle when injected into damaged organs. This suggests that the functional benefit seen in clinical trials may arise from other mechanisms (for example increased blood vessel formation), and raises the possibility that there may be alternative and perhaps more efficacious ways to accomplish this."
Both research teams injected bone-marrow-derived hematopoetic stem cells into the damaged hearts of living mice and used marker proteins to monitor the injected cells. They report that although some of the transplanted cells appeared to survive, they did not appear to differentiate into new heart muscle cells. Instead they matured into cells of the traditional blood lineage.
Cindy Fox Aisen | EurekAlert!
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
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09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
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