Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New findings on nerve cell proteins show promise for reducing disability

17.03.2004


New findings in animals suggest a potential treatment to minimize disability after spinal cord and other nervous system injuries, say neuroscientists from Wake Forest University Baptist Medical Center.



"Our approach is based on a natural mechanism cells have for protecting themselves, called the stress protein response," said Michael Tytell, Ph.D., a neuroscientist and the study’s lead researcher. "We believe it has potential for preventing some of the disability that occurs as a result of nervous system trauma and disease."

The research showed that up to 50 percent of the motor and sensory nerve cell death could be prevented in mice with sciatic nerve injury. It is reported in the current issue of Cell Stress and Chaperones, a journal of stress biology and medicine.


"We are on our way to developing a treatment that is effective in preventing motor nerve cell death, which is significant to people because loss of motor neurons means paralysis," said Tytell, professor of neurobiology and anatomy at Wake Forest Baptist.

The goal of the work is to prevent or minimize the "secondary" cell death that occurs in the hours and days after a spinal cord or brain injury. During this period, cells surrounding the injury can become inflamed and die, a cascading response that worsens disability.

"There is a lot of cell death that takes place after the initial injury," said Tytell. "If you could prevent that, you would retain a lot more function."

Tytell’s approach is to augment the stress protein response, in which cells produce proteins called Hsc70 and Hsp70 that help protect them from death when they are exposed to heat, injury or any other stresses that threaten their normal function.

"This is a way cells have of protecting themselves," he said. "If we can figure out a way to facilitate that response, we could potentially limit the amount of damage that is caused."

For the study, the researchers treated injured sciatic nerves in mice with Hsc70 and Hsp70. In mice treated with the proteins, cell death was reduced by up to 50 percent compared to mice that weren’t treated.

Tytell said it is a novel idea that cells can be successfully treated with a protein that is ordinarily made inside the cells.

"We don’t know whether the protein is functioning in the same way as when it’s made in the cells," he said. "We’re working to learn more about this effect. If we can understand it better, we’ll know what form it should be in and what the doses should be to maximize the protective benefits."

Tytell and colleagues hope to use their knowledge about the proteins and how they work to develop drugs that could be used to treat injury. One idea is to develop a drug that would increase the production of the protective proteins.

Tytell said that over the years, there has been little progress in research on traumatic injury to the nervous system. One approach that is being studied is to replace the damaged cells with stem cells. However, there are technical problems getting the nerve "circuitry" to grow back to normal. He believes the idea of protecting cells from secondary cell death deserves additional research attention.

"That’s a goal we could potentially reach more quickly than replacing cells that are lost," he said.

A long-range goal is to determine if the proteins could be useful in the treatment of degenerative diseases of the brain, such as Alzheimer’s disease and Huntington’s disease. The research was supported by a grant from the Muscular Dystrophy Association, a Wake Forest University School of Medicine Venture Grant, and a private donation.

Tytell and Wake Forest hold a U.S. Patent on the use of Hsc70 and Hsp70 to prevent the death of injured cells. The results in the report will contribute to his efforts and those of his co-author, Lucien J. Houenou, a former faculty member of Wake Forest University School of Medicine, to develop therapeutic agents based on the cellular stress response.

Media Contacts: Karen Richardson, krchrdsn@wfubmc.edu, or Shannon Koontz, shkoontz@wfubmc.edu, at 336-716-4587.

About Wake Forest University Baptist Medical Center: Wake Forest Baptist is an academic health system comprised of North Carolina Baptist Hospital and Wake Forest University School of Medicine. It is licensed to operate 1,282 acute care, psychiatric, rehabilitation and long-term care beds and is consistently ranked as one of "America’s Best Hospitals" by U.S. News & World Report.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu/

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Transport of molecular motors into cilia

28.03.2017 | Life Sciences

A novel hybrid UAV that may change the way people operate drones

28.03.2017 | Information Technology

NASA spacecraft investigate clues in radiation belts

28.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>