Scientists at the Carnegie Institution in Baltimore, MD, have found that certain cells involved in egg development in the fruitfly can be stimulated to revert to fully functioning stem cells. "This finding could lead to new sources of stem cells from other tissues and other animals," commented Dr. Allan Spradling, director of the Carnegie department and co-author of the study published in the March 14 online issue of Nature.
The research conducted by Spradling — a Howard Hughes Medical Institute Investigator — and colleague Dr. Toshie Kai, involved so-called germline stem cells of the female fruitfly. These cells are precursors to eggs and begin their journey as stem cells living in a special environment called a niche. In the niche, a stem cell splits into two daughter cells, one of which leaves the niche to begin its transformation. Through a series of 4 divisions a cluster of 16 cells forms — an immature egg with 15 accompanying nurse cells. The researchers discovered that the cells in clusters of 4 and 8 cells can still return to the stem-cell state under appropriate conditions. Moreover, the reverted stem cells worked as well as normal stem cells. Flies with only reverted stem cells were as fertile as normal flies throughout adult life.
"For most stem cells, it has not been possible yet to determine how quickly their progeny cells lose the ability to function again as stem cells," Spradling noted. "In the fruitfly (Drosophila) ovary we could directly test this and found conditions where the cluster cells reverted to a stem-cell state and functioned throughout the entire life of the adult. We dont know yet if this will be a general result that applies to other stem cells," cautioned Kai. "The progeny of germline stem cells might develop relatively slowly compared with other stem cell progeny, and thus retain their stemness longer."
Dr. Allan Spradling | EurekAlert!
Transport of molecular motors into cilia
28.03.2017 | Aarhus University
Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Materials Sciences
29.03.2017 | Physics and Astronomy
29.03.2017 | Earth Sciences