Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Method produces uniform, self-assembled nanocells

12.03.2004


Nanotechnology is about making improved products by building them from components hundreds of times smaller than a human blood cell. But how do you put things together at such a tiny scale? One way is to create the right conditions, so that they assemble themselves.


The peaks on this three-dimensional plot indicate a high concentration of liposomes forming in a microchannel.



For example, a new method for producing uniform, self-assembled nanocells has been developed by researchers at the National Institute of Standards and Technology (NIST). Reported in the March 10 issue of the Journal of the American Chemical Society, the method may have applications as an improved method for encapsulating drug therapies. A patent application has been filed.

Current bulk methods for producing nanocells called liposomes---a type of artificial cell---produce particles in a wide range of sizes. The sizes must be sorted and filtered before being used for drug delivery, since dosage depends critically on size.


The new NIST method uses micrometer-size channels etched into a device to produce self-assembled liposomes of specific sizes from as large as about 240 nanometers (nm) to as small as about 100 nm. A stream of natural fats (lipids) dissolved in alcohol is directed at an intersection of two channels that looks like a micro version of a four-way stop. A water-based liquid containing medicines or other substances is sent toward the lipid stream from two opposing directions. Rather than mixing with the water, the lipids surround it, forming self-assembled nanocells.

Controlling flow rates in the microchannels produces nanocells of specific sizes. Faster flows produce smaller cells. Medicine-filled liposomes made in nanosizes should allow for more accurate drug delivery. In particular, liposomes have been studied for years as a way to concentrate the effectiveness of cancer chemotherapy while minimizing harmful side effects.

Scott Nance | EurekAlert!

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>