Every cell in the body has what James Spudich, PhD, calls "a dynamic city plan" comprised of molecular highways, construction crews, street signs, cars, fuel and exhaust. Maintenance of this highly organized structure is fundamental to the development and function of all cells, Spudich says, and much of it can be understood by figuring out how the molecular motors do the work to keep cells orderly.
Spudich, biochemistry professor at the Stanford University School of Medicine, and Stanford physics graduate student David M. Altman report in the March 5 issue of Cell how a type of molecular motor provides the rigidity needed by the tiny sensors in the inner ear in order to respond to sound. They found that this motor creates the proper amount of tension in the sensors and anchors itself to maintain that tension.
"Our general feeling is that tension-sensitive machines are at the heart of the dynamic city plan," said Spudich. Their National Institutes of Health-funded study has implications far beyond how an obscure molecule provides rigidity for a protein in the inner ear. A motor able to create structural changes by taking up slack in proteins and clamping down so that they remain in a rigid position may help explain many intricacies of cellular organization, such as how chromosomes line up and separate during cell division.
Mitzi Baker | EurekAlert!
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26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
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Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy