Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Migraine mouse provides insight into neurobiology of devastating headaches

04.03.2004


Scientists have created a mouse model for migraine headache that may serve as an invaluable tool for future study of these debilitating headaches that are often accompanied by severe neurological symptoms. The research, published in the March 4 issue of Neuron, is a major step towards development of more successful treatments targeted at specific neurobiological events that underlie migraines.




Migraine is a common, chronic disorder characterized by recurrent disabling headaches. Approximately one-third of migraine sufferers have headaches preceded by a transient neurological aura of flashing jagged lights and pins and needles. Researchers from Leiden University Medical Centre in The Netherlands and the University of Padova and CNR Institute of Neuroscience in Italy examined a rare subtype of migraine called familial hemiplegic migraine (FHM) that is identical to other types of migraine except it is also associated with hemiparesis, weakness on one side of the body. FHM is associated with specific genetic mutations in a gene for a calcium channel protein that is involved in neuronal excitability. The researchers used a sophisticated genetic technique to create mice with a mutation seen in humans with FHM. Compared to normal mice, the migraine mice showed activation of calcium channels by weaker stimuli with consequent enhanced calcium entry into neurons, increased release of excitatory neurotransmitters, and increased susceptibility to cortical spreading depression (CSD), the phenomenon that underlies the migraine aura. "Previous studies have indicated that CSD is a wave of intense neuronal activity along the surface of the brain, followed by a long-lasting neuronal suppression. Our results suggest that in the migraine brain cortical hyperexcitability results in an increased susceptibility for CSD and aura," explains study coauthor Dr. Arn M.J.M. van den Maagdenberg.

The authors suggest that further studies are needed to identify a concrete link between FHM mutations, CSD, and activation of pain in the brain. According to coauthor Dr. Daniela Pietrobon, "Other studies have implicated CSD as a trigger for the pain associated with migraine. Drugs which reduce the activity of calcium channels in the migraine brain may make the brain more resistant to CSD and may thus be able to prevent migraine attacks." The FHM migraine mouse will provide a unique tool for future studies into the mechanisms of migraine as well as a promising model for testing new treatments aimed at preventing migraine by reducing hyperexcitability and preventing CSD.


Arn M.J.M. van den Maagdenberg, Daniela Pietrobon, Tommaso Pizzorusso, Simon Kaja, Ludo A.M. Broos, Tiziana Cesetti, Rob C.G. van de Ven, Angelita Tottene, Jos van der Kaa, Jaap J. Plomp, Rune R. Frants, and Michel D. Ferrari: "A Cacna1a Knockin Migraine Mouse Model with Increased Susceptibility to Cortical Spreading Depression"


Published in Neuron, Volume 41, Number 5, 4 March 2004, pages 701-710.

Heidi Hardman | EurekAlert!

More articles from Life Sciences:

nachricht Are there sustainable solutions in dealing with dwindling phosphorus resources?
16.10.2017 | Leibniz-Institut für Nutzierbiologie (FBN)

nachricht Strange undertakings: ant queens bury dead to prevent disease
13.10.2017 | Institute of Science and Technology Austria

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

Im Focus: New nanomaterial can extract hydrogen fuel from seawater

Hybrid material converts more sunlight and can weather seawater's harsh conditions

It's possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF...

Im Focus: Small collisions make big impact on Mercury's thin atmosphere

Mercury, our smallest planetary neighbor, has very little to call an atmosphere, but it does have a strange weather pattern: morning micro-meteor showers.

Recent modeling along with previously published results from NASA's MESSENGER spacecraft -- short for Mercury Surface, Space Environment, Geochemistry and...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

Conference Week RRR2017 on Renewable Resources from Wet and Rewetted Peatlands

28.09.2017 | Event News

 
Latest News

A single photon reveals quantum entanglement of 16 million atoms

16.10.2017 | Physics and Astronomy

The melting ice makes the sea around Greenland less saline

16.10.2017 | Earth Sciences

On the generation of solar spicules and Alfvenic waves

16.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>