A nanoscale imaging technique that could improve the reliability of an important diagnostic test for breast cancer, and other biomedical tests, is described by National Institute of Standards and Technology (NIST) researchers in the Feb. 11 online issue of Nucleic Acids Research.
The method involves attaching fluorescent particles just 15 nanometers (billionths of a meter) in diameter to particular sections of DNA, followed by analysis of the intensity of the fluorescence signal and other properties. These particles, called quantum dots, have unique electronic and optical properties that make them easier to detect than conventional fluorescent tags used in biomedical research. The NIST team demonstrated that quantum dots give off signals that are 200 to 1,100 percent more intense than those from two types of conventional tags, and also are more stable when exposed to light.
The new technique is a spin-off of an ongoing NIST effort to develop standards for a test that identifies breast cancer patients who would benefit from a particular drug therapy. The standards are expected to help reduce uncertainty in the so-called FISH (fluorescence in situ hybridization) test that detects a particular gene. Excess copies of this gene result in over-production of a protein and cause tumor cells to grow rapidly. Potentially, quantum dots could be used to tag these genes.
Laura Ost | EurekAlert!
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Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
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