A group of scientists at The Scripps Research Institute has solved the structure of a protein that regulates the expression of genes by controlling the stability of mRNA -- an intermediate form of genetic information between DNA genes and proteins.
"Gene expression can be controlled at many levels, " says Scripps Research Professor Peter Wright, Ph.D., who is chairman of the Department of Molecular Biology and Cecil H. and Ida M. Green Investigator in Medical Research at Scripps Research. "One of them is at the level of the message."
The structure of the "tandem zinc finger" domain of the regulatory protein TIS11d in complex with a strand of mRNA was solved in the laboratory of Wright and H. Jane Dyson, Ph.D., by Maria A. Martinez-Yamout, Ph.D., of Scripps Research, and Brian P. Hudson, Ph.D., of Rutgers University. This is the first such structure to be solved, and it provides insights into the process of gene regulation at the atomic level.
Keith McKeown | EurekAlert!
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