Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Acinetobacter baumannii, the hospital opportunist

12.01.2004


Acinetobacter baumannii is an opportunistic pathogen operating in hospitals creating serious infections such as pneumonia. It principally affects patients who have weakened health and this is why we call it opportunistic. Moreover, the mortality rate from these infections are usually high given, on the one hand, the weakness of the patient and, on the other, A. baumannii is resistant to many antibiotics. Furthermore, once a specific course of treatment is prescribed for A. Baumannii, the pathogen has a great capacity for acquiring resistance to these antibiotics.



To tackle this problem it is essential to observe, in an ongoing manner, the new resistances the bacteria develops, in order to know what kind of antibiotic has to be used to treat patients. In order to carry out these analyses, the gene for the new acquired resistance has to be identified and isolated and also the presence or otherwise of integrons has to be determined.

Integrons


Integrons are chains of genes wherein many of the resistances acquired by the A. baumannii bacteria are found. The pathogen also has other options for their acquisition but it is the integrons that provide the most efficacious way to acquire and transmit the resistances, given that, apart from acquiring resistances, integrons have great mobility and can transfer from one location of the A. baumannii chromosome to another.

This mobility allows them to pass from one strain of the bacteria to another. This means that all the resistances acquired by a strain of A. baumannii can be transmitted to another and the species can thus modify and regenerate itself continuously. Moreover, as it has a promotoros, the bacteria is always activating or expressing all the resistances held in the integron.

Attempting to improve control

Analysing and isolating a number of A. baumannii strains from hospitals, it has been shown that most have integrons. Thus, it is highly probable that A. baumannii becomes resistant to the best antibiotics that exist today and that this resistance is transmitted via integrons. Moreover, A. baumannii strains have been identified that are resistant to the most common antibiotics used today.

If this is confirmed, the mortality rate due to infections created by the bacteria may even be greater than thought to date, given that there is no antibiotic capable of tackling the infection. It should be taken into account that the number of hospital patients affected by infections caused by A. baumannii is not great, but the gravity of the problem lies in the rate of mortality of these cases.

There currently exist methods to genetically distinguish A. baumannii strains from each other, but the aim at the moment is to obtain a method of indicating the presence of integrons and their resistance in these strains. Of course, this method of detection has to be standardised and, at the same time, practical, for its clinical use.

That is to say, the option of the researchers has been to try to improve control with respect to A. baumannii given that there is currently no substitutes for the antibiotics used to date. In order to achieve this improved control, it is essential to detect the infection in time and know if A. baumannii has produced it. The resistances of the strains must also be known and if they have integrons. Once this detailed information is gathered, new systems for the control of infections can be introduced in order keep down the rate of mortality due to A. baumannii.


Contact :
Garazi Andonegi
ELHUYAR Fundazioa
garazi@elhuyar.com
(+34) 943363040

Garazi Andonegi | Basque research
Further information:
http://www.basqueresearch.com/berria_irakurri.asp?Gelaxka=1_1&Berri_Kod=383&hizk=I
http://www.ehu.es

More articles from Life Sciences:

nachricht New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego

nachricht Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Gran Chaco: Biodiversity at High Risk

17.01.2018 | Ecology, The Environment and Conservation

Only an atom thick: Physicists succeed in measuring mechanical properties of 2D monolayer materials

17.01.2018 | Physics and Astronomy

Fraunhofer HHI receives AIS Technology Innovation Award 2018 for 3D Human Body Reconstruction

17.01.2018 | Awards Funding

VideoLinks
B2B-VideoLinks
More VideoLinks >>>