By revealing the architecture of an essential enzyme in a parasite, Dartmouth researchers are helping address a public health issue.
Researchers in the laboratory of Amy Anderson, Assistant Professor of Chemistry, have unveiled the structure of an enzyme called dihydrofolate reductase-thymidylate synthase, also known as DHFR-TS, from a waterborne parasite called Cryptosporidium hominis. Knowing the chemical structure of the enzyme will help researchers design highly targeted drugs to combat the parasite, which needs this enzyme to reproduce.
"We wanted to know how DHFR-TS is assembled and how it works," says Anderson. "Then well know how to disable it and kill the parasite."
Sue Knapp | EurekAlert!
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