Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Ohio State creates gene chip for horse

16.12.2003


Alicia Bertone


Researchers at Ohio State University have created a DNA gene chip that contains thousands of the genes for a horse and one of the first gene chips for a domestic animal.

The new chip houses more than 3,200 expressed horse genes on a sliver of glass about the size of a postage stamp. When the researchers began developing this chip two years ago, only 200 horse genes were known.

This new chip will allow researchers to scan an individual horses genes at once to see which ones are active in a certain situation. For example, drug companies might use a gene chip to predict how a particular drug will affect an animal.



Since their invention nearly a decade ago, gene chips have revolutionized some basic approaches to research. Having a representative gene chip for a large animal could lead to better accuracy in studying human disease. Commercial gene chips already exist for humans, mice, rats, rice plants and a number of microorganisms.

"Although we rely on animal models to study human diseases, we really aren’t sure what some of the genetic differences are between those animal models and humans," said Alicia Bertone, the professor of veterinary clinical sciences who led Ohio State’s efforts in developing the equine gene chip.

"The genetic differences between humans and most animals are small in most cases, more than 90 percent of our DNA is similar," Bertone said. Knowing which genes are similar can be a boon to researchers who use animal models to learn about human diseases.

"Gene chips can help uncover these key differences, giving us critical information before we launch into an experiment," Bertone said. "The scientific community has invested a lot of money in animal models that don’t truly represent the human situation, so having this kind of information is extremely beneficial."

Bertone developed the chip with the help of Weisong Gu, a postdoctoral researcher in veterinary clinical sciences at Ohio State. Gu created a computer program that helped he and Bertone discover and describe 3,088 horse genes. They added these genes to the 200 already-known genes to create the chip. In order to define the genes, the researchers compared sequences of horse DNA to already-known human genes. Bertone said there are likely thousands of more genes yet to be identified for the horse.

Data derived from the equine gene chip could give researchers insight into gene expression for specific equine and human diseases and conditions. For example, gene chips let researchers see how thousands of genes respond to an illness. This information can be used clinically to study disease in horses and in translational research from horse to human.

"The closer we can demonstrate that an animal model really mimics a human disease, the better off we are," said Bertone, adding that horses are often used as models for orthopedic diseases, such as osteoarthritis and osteochondrosis a disease that inhibits bone growth. The equine gene chip can also be used to identify horse diseases such as equine protozoal myelitis (EPM), a debilitating neurological disease. Also, testing a drug or other therapy is typically done in large animals, such as horses, dogs and cats, before being tested on humans.

"More accurate animal models mean we’ll spend less money on and use fewer animals for finding cures," Bertone said. "Billions of dollars are invested in developing drugs that work really well in mice but fail in larger animal models and humans."

The new equine chip includes genes that regulate cell death, the cell cycle, cell signaling and development. The cost of the chip is around $350 to $450.

This work was supported in part by Affymetrix, Inc., the manufacturer of a variety of gene chips.


Contact: Alicia Bertone, 614-292-6661; Bertone.1@osu.edu
Written by Holly Wagner, (614) 292-8310; Wagner.235@osu.edu

Holly Wagner | OSU
Further information:
http://researchnews.osu.edu/archive/genechip.htm

More articles from Life Sciences:

nachricht Individual Receptors Caught at Work
19.10.2017 | Julius-Maximilians-Universität Würzburg

nachricht Rapid environmental change makes species more vulnerable to extinction
19.10.2017 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Electrode materials from the microwave oven

19.10.2017 | Materials Sciences

New material for digital memories of the future

19.10.2017 | Materials Sciences

Physics boosts artificial intelligence methods

19.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>