The measurement of new genes at diagnosis in children with acute lymphoblastic leukemia (ALL), discovered through new technologies from the human genome project, may be highly predictive of therapeutic outcomes, according to a study presented today during the 45th Annual Meeting of the American Society of Hematology (ASH). OPAL 1 (Outcome Predictor in Acute Leukemia 1), a novel, fully cloned human gene, and additional newly identified genes, have a strong predictive power to identify patients who may achieve remission or fail current therapeutic regimens for pediatric ALL, allowing physicians to tailor therapies more effectively to individual children with leukemia.
Study results showed that 87 percent of the patients with ALL and high OPAL 1 achieved long-term remission, compared to an overall outcome of 32 percent of all patients studied. OPAL1 was also highly predictive of a favorable outcome in T-cell ALL, and a similar trend was observed in infant ALL. Low OPAL1 was associated with induction failure, while high OPAL1 was associated with long-term event free survival, particularly in males. Eighty-six percent of ALL cases with t(12;21), which has prognostic value in ALL, and high OPAL1 achieved long term remission compared to only 35 percent of t(12;21) cases with low OPAL1, suggesting that OPAL1 may be useful in prospectively identifying children who may benefit from further intensification.
"Our study confirms that gene expression profiling can yield novel genes that may be used to improve risk classification and outcome prediction in acute leukemia in children," said Cheryl L. Willman, M.D., of the University of New Mexico Health Sciences Center, Albuquerque, N.M., senior author of the study. "Improving risk classification schemes in order to precisely tailor treatment regimens to individual patients has long been a major challenge for pediatric ALL, and is a goal of the National Childrens Oncology Group and the National Cancer Institute, which have supported our work. We believe that our research brings us closer to achieving this goal."
Aimee Frank | EurekAlert!
More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
19.01.2018 | Life Sciences
19.01.2018 | Life Sciences
19.01.2018 | Physics and Astronomy