Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Findings offer clue to how molecule can both stimulate, suppress cell growth

04.12.2003


Study provides insight into role of TGF-beta in cancer development, progression



Scientists are puzzled by the fact that the molecule known as transforming growth factor-beta (TGF-b) generally stops cells from multiplying but at other times promotes cell growth.

Dr. Hal Moses, director of the Vanderbilt-Ingram Cancer Center, and his lab identified TGF-b in 1985 as both a growth stimulator and growth suppressor. Since that time, its role in colon, breast and other cancers has been studied extensively at Vanderbilt and elsewhere.


Now a team of researchers at Vanderbilt-Ingram has found a clue to the seemingly contradictory biological actions of TGF-b. Their findings are published online this week by the Proceedings of the National Academy of Science (www.pnas.org) and is expected to appear in the print version later this month.

"TGF-b usually causes cell growth inhibition; however, many solid tumors over-express TGF-b and the cells aren’t inhibited at all – in fact, sometimes they grow faster than normal as a result of TGF-b signaling," said Neil A. Bhowmick, Ph.D., assistant professor of Urologic Surgery and senior author on the paper. "Many researchers have studied the ways in which TGF-b suppresses cell growth but not many have examined how it promotes cell growth."

The researchers studied normal cells lines whose growth was inhibited by TGF-b -- the process was working properly – as well as cell lines whose growth was stimulated by TGF-b.

TGF-b uses multiple signaling pathways to get its instructions to the cell’s nucleus – at least four pathways that are known, and there are probably more, Bhowmick said.

In the inhibited cells, the researchers removed particular protein components in one of these known TGF-b signaling pathways called Rho-ROCK. The cells were no longer inhibited and instead began growing again.

Then they did the opposite, adding the protein components to cells whose growth was being stimulated by TGF-b to see if their growth would be arrested again – that is, if normal TGF-b function would be restored by restoring the pathway. "Lo and behold, that’s exactly what happened," Bhowmick said.

The findings suggest that the Rho-ROCK signaling pathway, traditionally known for its involvement in cell differentiation and defining cell shape, plays a key role in TGF-b inhibition of cell growth. "Perhaps inactivation of this pathway is a way that cancer cells override the normal growth-suppressing activity of TGF-b," Bhowmick said.

More work is needed to fully understand the implications, but the findings also suggest a potential target for therapeutic intervention to restore TGF-b’s ability to inhibit cell growth, he said.

Bhowmick’s co-authors on the paper were Mayshan Ghiassi, Mary Aakre, Kimberly Brown, Vikas Singh and Moses, members of the department of Cancer Biology and the Frances Williams Preston Laboratories, supported by the T.J. Martell Foundation at Vanderbilt-Ingram.


The work was supported by the U.S. Department of Defense, the National Cancer Institute and the Vanderbilt-Ingram Cancer Center.

The Vanderbilt-Ingram Cancer Center is the only National Cancer Institute-designated Comprehensive Cancer Center in Tennessee and one of only 38 in the United States. This designation is the highest awarded by the NCI, one of the National Institutes of Health and world’s foremost authority on cancer. It recognizes excellence in all aspects of cancer research, the development of innovative new therapies and a demonstrated commitment to the community through education, information and outreach. For more information, visit www.vicc.org.

Cynthia Floyd Manley | EurekAlert!
Further information:
http://www.vicc.org

More articles from Life Sciences:

nachricht Cells migrate collectively by intermittent bursts of activity
30.09.2016 | Aalto University

nachricht The structure of the BinAB toxin revealed: one small step for Man, a major problem for mosquitoes!
30.09.2016 | CNRS (Délégation Paris Michel-Ange)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-Ever 3D Printed Excavator Project Advances Large-Scale Additive Manufacturing R&D

Heavy construction machinery is the focus of Oak Ridge National Laboratory’s latest advance in additive manufacturing research. With industry partners and university students, ORNL researchers are designing and producing the world’s first 3D printed excavator, a prototype that will leverage large-scale AM technologies and explore the feasibility of printing with metal alloys.

Increasing the size and speed of metal-based 3D printing techniques, using low-cost alloys like steel and aluminum, could create new industrial applications...

Im Focus: New welding process joins dissimilar sheets better

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Paper – Panacea Green Infrastructure?

30.09.2016 | Event News

HLF: From an experiment to an establishment

29.09.2016 | Event News

European Health Forum Gastein 2016 kicks off today

28.09.2016 | Event News

 
Latest News

First-Ever 3D Printed Excavator Project Advances Large-Scale Additive Manufacturing R&D

30.09.2016 | Materials Sciences

New Technique for Finding Weakness in Earth’s Crust

30.09.2016 | Earth Sciences

Cells migrate collectively by intermittent bursts of activity

30.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>