Researchers led by Jason Jaworski, PhD, and Michael Kuhar, PhD, both at the Yerkes National Primate Research Center at Emory University, have shown that CART peptide, a chemical that occurs naturally in both the rodent and human brain, reduces some effects of cocaine when additional amounts are administered to the region of the brain that is associated with reward and addiction. These findings, which were presented on November 8 at the Society for Neuroscience meeting in New Orleans, appear in the December issue of the Journal of Pharmacology and Experimental Therapeutics and suggest CART peptide receptors in the brain could be targets for developing medications to treat cocaine abuse.
For their study, Dr. Jaworski, a post-doctoral fellow, and Dr. Kuhar, chief of the Neuroscience Division at Yerkes and a Georgia Research Alliance Eminent Scholar, infused CART peptide into the nucleus accumbens (NA) of rodents to determine how it affects the increase of body movement, or locomotor activity, that is widely seen as one effect of psychostimulant drugs. The researchers observed that the cocaine-induced movement was reduced after the rodents received CART peptide. "This is the first study to demonstrate CART peptides in the nucleus accumbens hinder the effects of cocaine," said Dr. Jaworski. "Our findings open a door to develop potential treatment options for cocaine addiction."
When infused into other areas of the "pleasure pathway," the part of the brain in both rodents and humans that is activated when cocaine is administered, CART peptide has been shown to produce minimal psychostimulant-like effects. "Past studies have shown CART peptide is slightly cocaine-like in other areas of the brain, but nevertheless inhibits further stimulation from the drug," said Dr. Kuhar. "While additional research will be necessary, we have demonstrated the importance of CART peptide in combating or slowing down some of the effects of cocaine."
Lisa Newbern | EurekAlert!
Nesting aids make agricultural fields attractive for bees
20.07.2017 | Julius-Maximilians-Universität Würzburg
The Kitchen Sponge – Breeding Ground for Germs
20.07.2017 | Hochschule Furtwangen
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
19.07.2017 | Event News
12.07.2017 | Event News
12.07.2017 | Event News
20.07.2017 | Information Technology
20.07.2017 | Materials Sciences
20.07.2017 | Physics and Astronomy