Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UIC researchers create tissue-engineered joint from stem cells

01.12.2003


Researchers at the University of Illinois at Chicago have successfully turned adult stem cells into bone and cartilage, forming the ball structure of a joint found in the human jaw with its characteristic shape and tissue composition.



Tested so far only in animals, the tissue-engineering procedure to create a human-shaped articular condyle could be used one day to regenerate the ball structure of joints in the jaw, knee and hip that have been lost to injury or diseases such as arthritis.

"This represents the first time a human-shaped articular condyle with both cartilage- and bone-like tissues was grown from a single population of adult stem cells," said Jeremy Mao, director of the tissue engineering laboratory at UIC and associate professor of bioengineering and orthodontics.


"Our ultimate goal is to create a condyle that is biologically viable -- a living tissue construct that integrates with existing bone and functions like the natural joint."

To create the articular condyle, Mao and Adel Alhadlaq, a doctoral student in anatomy and cell biology, used adult mesenchymal stem cells taken from the bone marrow of rats. Bone marrow is the inner, spongy tissue of long bones like the femur and tibia, the leg bones.

Under certain conditions, mesenchymal stem cells, present in a number of adult tissues, can potentially differentiate into virtually any kind of connective tissue -- including tendons, skeletal muscle, teeth, ligaments, cartilage and bone.

Using chemical substances and growth factors, the scientists induced the adult stem cells to develop into cells capable of producing cartilage and bone.

The cells were then stratified into two integrated layers, encapsulated in a biocompatible gel-like material, and shaped into an articular condyle using a mold made from the temporomandibular or jaw joint of a human cadaver.

After several weeks, Mao and his colleagues found that the tissue-engineered structures retained the molded shape of the human mandibular condyle, with bone-like tissue underneath and a layer of cartilage-like tissue on top -- an arrangement similar to that of a natural articular condyle.

Moreover, multiple tests confirmed that the newly grown tissues were indeed bone and cartilage, having the characteristic microscopic components: for bone, a matrix of collagen with deposits of calcium salts, and for cartilage, collagen and large amounts of substances called proteoglycans.

Mao stressed that much additional work is needed before tissue-engineered condyles are ready for therapeutic use in patients suffering from osteoarthritis, rheumatoid arthritis, injuries or congenital anomalies.

Nevertheless, he believes that with further refinements, the procedure could one day be adopted for total hip and knee replacements.

"Our findings represent a proof of concept for further development of tissue-engineered condyles," Mao said.

The first in a series of reports on the tissue-engineered articular condyle will be published as a rapid communication in the December issue of the Journal of Dental Research.

###
Mao’s tissue engineering laboratory is funded by multiple grants from the National Institutes of Health and the Whitaker Foundation.

For more information about UIC, visit www.uic.edu.

Sharon Butler | EurekAlert!
Further information:
http://www.uic.edu

More articles from Life Sciences:

nachricht What the world's tiniest 'monster truck' reveals
23.08.2017 | American Chemical Society

nachricht Treating arthritis with algae
23.08.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Researchers devise microreactor to study formation of methane hydrate

23.08.2017 | Materials Sciences

ShAPEing the future of magnesium car parts

23.08.2017 | Automotive Engineering

New insights into the world of trypanosomes

23.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>