Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UIC researchers create tissue-engineered joint from stem cells

01.12.2003


Researchers at the University of Illinois at Chicago have successfully turned adult stem cells into bone and cartilage, forming the ball structure of a joint found in the human jaw with its characteristic shape and tissue composition.



Tested so far only in animals, the tissue-engineering procedure to create a human-shaped articular condyle could be used one day to regenerate the ball structure of joints in the jaw, knee and hip that have been lost to injury or diseases such as arthritis.

"This represents the first time a human-shaped articular condyle with both cartilage- and bone-like tissues was grown from a single population of adult stem cells," said Jeremy Mao, director of the tissue engineering laboratory at UIC and associate professor of bioengineering and orthodontics.


"Our ultimate goal is to create a condyle that is biologically viable -- a living tissue construct that integrates with existing bone and functions like the natural joint."

To create the articular condyle, Mao and Adel Alhadlaq, a doctoral student in anatomy and cell biology, used adult mesenchymal stem cells taken from the bone marrow of rats. Bone marrow is the inner, spongy tissue of long bones like the femur and tibia, the leg bones.

Under certain conditions, mesenchymal stem cells, present in a number of adult tissues, can potentially differentiate into virtually any kind of connective tissue -- including tendons, skeletal muscle, teeth, ligaments, cartilage and bone.

Using chemical substances and growth factors, the scientists induced the adult stem cells to develop into cells capable of producing cartilage and bone.

The cells were then stratified into two integrated layers, encapsulated in a biocompatible gel-like material, and shaped into an articular condyle using a mold made from the temporomandibular or jaw joint of a human cadaver.

After several weeks, Mao and his colleagues found that the tissue-engineered structures retained the molded shape of the human mandibular condyle, with bone-like tissue underneath and a layer of cartilage-like tissue on top -- an arrangement similar to that of a natural articular condyle.

Moreover, multiple tests confirmed that the newly grown tissues were indeed bone and cartilage, having the characteristic microscopic components: for bone, a matrix of collagen with deposits of calcium salts, and for cartilage, collagen and large amounts of substances called proteoglycans.

Mao stressed that much additional work is needed before tissue-engineered condyles are ready for therapeutic use in patients suffering from osteoarthritis, rheumatoid arthritis, injuries or congenital anomalies.

Nevertheless, he believes that with further refinements, the procedure could one day be adopted for total hip and knee replacements.

"Our findings represent a proof of concept for further development of tissue-engineered condyles," Mao said.

The first in a series of reports on the tissue-engineered articular condyle will be published as a rapid communication in the December issue of the Journal of Dental Research.

###
Mao’s tissue engineering laboratory is funded by multiple grants from the National Institutes of Health and the Whitaker Foundation.

For more information about UIC, visit www.uic.edu.

Sharon Butler | EurekAlert!
Further information:
http://www.uic.edu

More articles from Life Sciences:

nachricht Cells migrate collectively by intermittent bursts of activity
30.09.2016 | Aalto University

nachricht The structure of the BinAB toxin revealed: one small step for Man, a major problem for mosquitoes!
30.09.2016 | CNRS (Délégation Paris Michel-Ange)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-Ever 3D Printed Excavator Project Advances Large-Scale Additive Manufacturing R&D

Heavy construction machinery is the focus of Oak Ridge National Laboratory’s latest advance in additive manufacturing research. With industry partners and university students, ORNL researchers are designing and producing the world’s first 3D printed excavator, a prototype that will leverage large-scale AM technologies and explore the feasibility of printing with metal alloys.

Increasing the size and speed of metal-based 3D printing techniques, using low-cost alloys like steel and aluminum, could create new industrial applications...

Im Focus: New welding process joins dissimilar sheets better

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Paper – Panacea Green Infrastructure?

30.09.2016 | Event News

HLF: From an experiment to an establishment

29.09.2016 | Event News

European Health Forum Gastein 2016 kicks off today

28.09.2016 | Event News

 
Latest News

First-Ever 3D Printed Excavator Project Advances Large-Scale Additive Manufacturing R&D

30.09.2016 | Materials Sciences

New Technique for Finding Weakness in Earth’s Crust

30.09.2016 | Earth Sciences

Cells migrate collectively by intermittent bursts of activity

30.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>