Liver cells undergoing an autoimmune attack
Credit: Alejandro Villarino, University of Pennsylvania.
Since their discovery, cytokines have provided biomedical researchers with a tangled web of immune-system pathways to unknot. While most known cytokines have a role in stimulating immunity, one cytokine, IL-27, may actually suppress CD4 T cells, the helper T cells that orchestrate the immune system response to infections, according to researchers at the University of Pennsylvania School of Veterinary Medicine.
Their findings could provide researchers with a way to clamp down on dozens of autoimmune conditions caused by an overzealous immune system, such as Crohn disease, lupus or even sepsis. Their research is the cover article for the November issue of the journal Immunity.
"When the immune system is activated there is a cascade of cytokine interactions that regulate the growth and functions of an array of immune cells," said Christopher Hunter, an associate professor in Penn Department of Pathobiology and senior author of the paper. "Contrary to previous studies, the IL-27 cytokine actually limits the duration and intensity of T cell activation, an ’off switch’ as it were."
Greg Lester | University of Pennsylvania
Polymers Based on Boron?
18.01.2018 | Julius-Maximilians-Universität Würzburg
Bioengineered soft microfibers improve T-cell production
18.01.2018 | Columbia University School of Engineering and Applied Science
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
18.01.2018 | Life Sciences
18.01.2018 | Life Sciences
18.01.2018 | Earth Sciences