UT Southwestern Medical Center at Dallas researchers have shown that the absence of a key oxygen-sensing molecule can lead to multiple developmental defects - from an enlarged heart to eye problems.
The researchers generated the first mouse model that lacks entirely a member of an important family of proteins involved in sensing hypoxia, a state of reduced oxygen in the bodys cells that is associated with conditions such as heart attacks, stroke and lung disease.
This new model allowed the scientists to take a closer look into the exact physiologic function of these proteins, which was unknown until now, and the model provided clues as to what human diseases may be caused by alterations in these proteins. The researchers reported in the online version of Nature Genetics that the absence of this crucial oxygen-sensing molecule leads to developmental defects due to the inability of the mice to respond to high, damaging levels of oxygen-based molecules called reactive oxygen species.
Amy Shields | UT Southwestern
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Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
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Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
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For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
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An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
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A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
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