A research team at The University of Texas M. D. Anderson Cancer Center has found that a single protein known as ARF helps coordinate both growth and division within a cell -- the functions that are often perturbed in cancer development.
Many proteins have been found in cancer research that are associated with either errant cell division or with uncontrolled growth, but ARF is the first "master molecule" that seems to be involved in both crucial aspects of the cell cycle, say the researchers, who published their discovery in the November issue of the journal, Molecular Cell.
The work helps explain why so many human cancers -- more than 40 percent -- are found to have altered ARF proteins, says the studys lead author, Yanping Zhang, Ph.D., assistant professor in the Department of Molecular and Cellular Oncology.
Heather Russell | EurekAlert!
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