Researchers at UT Southwestern Medical Center at Dallas have shown that insulin family signaling is important for male sex determination, a discovery that furthers the understanding of testes formation and eventually could lead to treatments for reproductive disorders.
"Dr. Luis F. Parada (left) and Dr. Sunita Verma-Kurvari have found insulin family signaling is important for male sex determination, furthering the understanding of testes formation and perhaps someday leading to treatments for reproductive disorders."
Their findings appear in the current issue of Nature and are available online.
"We are excited by this research for two reasons," said Dr. Luis Parada, senior author of the Nature study and director of the Center for Developmental Biology. "First, the intracellular signaling pathways that mediate male sexual differentiation have remained elusive despite the fact that the controlling gene that unleashes the process was identified almost 15 years ago. Second, our experience with studying receptors and signaling in development provides us with the skills and tools to tackle this problem, which has tremendous implications in newborn disorders."
Scott Maier | UT Southwestern
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