Scientists are closing in on genetic contributors to high blood pressure and other causes of heart and cardiovascular disease. At the American Society for Human Genetics annual meeting in Los Angeles, Hopkins research associate Yen-Pei Christy Chang, Ph.D., will present evidence that a region of chromosome 1 is involved in appropriately regulating blood pressure. Her talk is scheduled for 10:15 a.m., Saturday, Nov. 8.
The scientists conducted a genome-wide analysis of 1,875 people in 585 families collected through the GenNet network of the National Heart, Lung and Blood Institutes Family Blood Pressure Program. Through their analysis, the scientists linked a region containing more than 200 known genes to blood pressure. The researchers also highlighted 24 genes whose functions might predict some role in hypertension, and closely examined nine of these genes. Their work uncovered genetic changes called single nucleotide polymorphisms (SNPs) in three of these nine that were associated with hypertension.
This region of chromosome 1 has been linked to related disorders such as type 2 diabetes and to a condition called familial hyperlipidemia (in which levels of cholesterol are high). However, this is the first analysis to identify candidate genes for additional study and to offer good evidence that more than one gene in the region is involved in blood pressure regulation, says the studys principal investigator, Aravinda Chakravarti, Ph.D., director of the McKusick-Nathans Institute of Genetic Medicine.
Joanna Downer | EurekAlert!
Repairing damaged hearts with self-healing heart cells
22.08.2017 | National University Health System
Biochemical 'fingerprints' reveal diabetes progression
22.08.2017 | Umea University
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
22.08.2017 | Health and Medicine
22.08.2017 | Materials Sciences
22.08.2017 | Life Sciences