Scientists are closing in on genetic contributors to high blood pressure and other causes of heart and cardiovascular disease. At the American Society for Human Genetics annual meeting in Los Angeles, Hopkins research associate Yen-Pei Christy Chang, Ph.D., will present evidence that a region of chromosome 1 is involved in appropriately regulating blood pressure. Her talk is scheduled for 10:15 a.m., Saturday, Nov. 8.
The scientists conducted a genome-wide analysis of 1,875 people in 585 families collected through the GenNet network of the National Heart, Lung and Blood Institutes Family Blood Pressure Program. Through their analysis, the scientists linked a region containing more than 200 known genes to blood pressure. The researchers also highlighted 24 genes whose functions might predict some role in hypertension, and closely examined nine of these genes. Their work uncovered genetic changes called single nucleotide polymorphisms (SNPs) in three of these nine that were associated with hypertension.
This region of chromosome 1 has been linked to related disorders such as type 2 diabetes and to a condition called familial hyperlipidemia (in which levels of cholesterol are high). However, this is the first analysis to identify candidate genes for additional study and to offer good evidence that more than one gene in the region is involved in blood pressure regulation, says the studys principal investigator, Aravinda Chakravarti, Ph.D., director of the McKusick-Nathans Institute of Genetic Medicine.
Joanna Downer | EurekAlert!
Gene therapy shows promise for treating Niemann-Pick disease type C1
27.10.2016 | NIH/National Human Genome Research Institute
'Neighbor maps' reveal the genome's 3-D shape
27.10.2016 | International School of Advanced Studies (SISSA)
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
27.10.2016 | Materials Sciences
27.10.2016 | Physics and Astronomy
27.10.2016 | Life Sciences