Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers Home In On Obesity Gene And Offer Explanation For Overeating

03.11.2003


An international team of researchers has identified the role of a gene which may explain why some people overeat and become obese.



Their research, published today in Public Library of Science Biology, shows that the gene GAD2 has an appetite stimulating role, and that one form of the gene is strongly associated with obese people.

While the researchers recognise that obesity is a result of the interactions of many genes and environmental factors, this is one of the first genes to be strongly touted as a candidate ‘gene for obesity’.


GAD2, which sits on chromosome 10, acts by speeding up production of a neurotransmitter in the brain called GABA, or gamma-amino butyric acid. When GABA interacts with another molecule named neuropeptide Y in a specific area of the brain - the paraventricular nucleus of the hypothalamus - we are stimulated to eat.

The researchers behind this study believe that people who carry a more active form of the GAD2 gene build up a larger than normal quantity of GABA in the hypothalamus, and suggest that this over accumulation of GABA drives the stimulus to eat further than normal, and is thus a basis for explaining why obese people overeat.

Professor Philippe Froguel, senior author of the research, from Imperial College London, and Hammersmith Hospital, London, and who carried out the research while at the Institut Pasteur de Lille, France, said: “The discovery that this one gene plays a role in determining whether someone is likely to overeat could be crucial in understanding the continued rise in obesity rates around the world.

“Genetic factors alone can not explain the rapid rise in obesity rates, but they may provide clues to preventative and therapeutic approaches that will ease the health burden associated with obesity.

“Having identified this gene, it may be possible to develop a screening programme to identify those who may be at risk of becoming obese later in life, and take effective preventative measures.”

The team compared genome-wide scans of 576 obese and 646 normal weight adults in France, from which they identified two alternative forms, or alleles, of the GAD2 gene.

One form of the gene was found to be protective against obesity, while another increased the risk of obesity. The normal weight group of French adults had a higher frequency of the protective form of the GAD2 gene. Obesity is three to five times less prevalent in France than in the USA.

In addition to the genome-wide scans, the obese patients also completed an eating habits questionnaire, measuring dietary restraint, disinhibition and perceived hunger. The results showed that those carrying the GAD2 allele that increases the risk of obesity were significantly more likely to reveal an inability to control their food intake, and perceive high levels of hunger.

Authors of this research are based at Imperial College London, Hammersmith Hospital, London, the Institut Pasteur de Lille, France, the University of Washington, USA, Paul Brousse Hospital, and Paris VI University, France.

Tony Stephenson | alfa
Further information:
http://www.imperial.ac.uk.
http://www.plosbiology.org

More articles from Life Sciences:

nachricht Individual Receptors Caught at Work
19.10.2017 | Julius-Maximilians-Universität Würzburg

nachricht Rapid environmental change makes species more vulnerable to extinction
19.10.2017 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Electrode materials from the microwave oven

19.10.2017 | Materials Sciences

New material for digital memories of the future

19.10.2017 | Materials Sciences

Physics boosts artificial intelligence methods

19.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>