Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCLA study identifies stem cell in artery wall

28.10.2003


A UCLA study demonstrates for the first time that specific cells found in the adult artery wall have stem cell-like potential. Researchers found artery cells that change into cartilage, bone, muscle and marrow stromal cells.



The new study will be published online on Oct. 27 and will appear in an upcoming print issue of the journal Circulation. The study may lead to a new source of adult stem cells, which may increase potential treatment options and avoid the controversial use of fetal stem cells.

"This is the first study to show that cells in the artery wall have the potential to develop into a number of other cell types," said Dr. Linda Demer, principal investigator, Guthman Professor of Medicine and Physiology, and vice chair for cardiovascular and vascular medicine at the David Geffen School of Medicine at UCLA.


UCLA researchers also report that the artery wall cells, called calcifying vascular cells (CVC), are the only cells other than actual bone marrow stromal cells that support survival of immature (developing) blood cells. This finding may have future applications in reconstitution of bone marrow after cancer treatment.

UCLA researchers cultured bovine CVC artery wall cells in the lab to see if the cells would turn into bone, fat, cartilage, marrow and muscle cells. They checked for expression of proteins and tissue matrix characteristic of each cell type.

"We wanted to see if CVC cells would become specific cell types that actually produce their own characteristic matrix (mortar-like) substance. For example, if the cell actually produced bone mineral, it would indicate that the cell had taken on a bone identity," said first author Yin Tintut, Division of Cardiology at the David Geffen School of Medicine at UCLA.

Researchers found that CVC cells had the potential to become several cell types, including bone, cartilage, marrow stromal and muscle cells, but not adipogenic, or fat, cells. Demer suggests this indicates that the CVC cells may not have the entire range of conventional stem cells. However, this may be especially useful in cases where one would not want the stem cell turning into a fat cell -- such as in trying to regenerate cartilage.

The next step involves "assessing CVC cells’ potential to follow other lineages and also testing human cells," Demer said.

Stem cells are young, uncommitted cells with the ability to regenerate more stem cells and to differentiate into a variety of cell types. Researchers can then grow cells in the lab and program them to make specific tissue that may be used to repair damaged tissues such as in reconstructive surgery.

Two institutes that are part of the National Institutes of Health funded the study: the National Heart, Lung and Blood Institute, and the National Institute of Arthritis, Musculoskeletal and Skin Diseases.

Other researchers include Zeni Alfonso from the UCLA department of urology; and Trishal Saini, Kristen Radcliff, Dr. Karol Watson and Dr. Kristina Boström from the UCLA department of medicine.

Rachel Champeau | EurekAlert!
Further information:
http://www.ucla.edu/

More articles from Life Sciences:

nachricht Scientists enlist engineered protein to battle the MERS virus
22.05.2017 | University of Toronto

nachricht Insight into enzyme's 3-D structure could cut biofuel costs
19.05.2017 | DOE/Los Alamos National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

Im Focus: Hydrogen Bonds Directly Detected for the First Time

For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.

Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

Media accreditation opens for historic year at European Health Forum Gastein

16.05.2017 | Event News

 
Latest News

New approach to revolutionize the production of molecular hydrogen

22.05.2017 | Materials Sciences

Scientists enlist engineered protein to battle the MERS virus

22.05.2017 | Life Sciences

Experts explain origins of topographic relief on Earth, Mars and Titan

22.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>