Purdue University biologists have determined the structure of the West Nile virus, a development that could greatly augment our understanding of the virus life cycle.
This figure shows a surface-shaded image of the West Nile virus particle produced by Purdue University biologists using cryoelectron microscopy. The surface is composed of proteins that enable the virus to bind with and invade a host cell. The particle is approximately 50 nanometers in diameter, or about 1/1000th of the width of a human hair. (Purdue Department of Biological Sciences image)
This image shows the orientation of the envelope protein molecules that compose the surface of a West Nile virus particle. The major surface protein is composed of three domains color-coded pink, yellow and blue. The proteins self-assemble in a host cell, forming a well-organized geometric shape. Knowledge of the proteins structure could help scientists in the effort to develop antiviral agents. (Purdue Department of Biological Sciences image)
Using cryoelectron microscopy and advanced imaging techniques, the Purdue team has determined the orientation of the major surface proteins in a West Nile viral particle. Because these proteins are instrumental in allowing the virus to bind to and invade a host cell, the research could be a step forward in combating the deadly mosquito-borne disease.
"We can now clearly understand how these proteins interact with one another," said Richard J. Kuhn, a professor of biological sciences in Purdues School of Science. "We cant cure West Nile yet, but we can now start thinking about how to interfere with these interactions, which could be a key to stopping the infections progress."
Chad Boutin | Purdue News
Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University
Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017
25.04.2017 | Laser Zentrum Hannover e.V.
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Physics and Astronomy
25.04.2017 | Materials Sciences
25.04.2017 | Life Sciences