Dendritic cells monitor foreign substances in the body and communicate whether they present a danger to the rest of the immune system. Emory immunologists have developed a sensitive method to detect and follow dendritic cells by marking them with a change in their DNA, and have discovered that they are more numerous and longer lived than other scientists had previously observed. Their research uses a gene gun, which shoots DNA into the skin using microscopic gold pellets, and could lead to a faster and simpler way to vaccinate against emerging diseases like West Nile virus, SARS, or hepatitis C.
The research was published online August 10, and will appear in the journal Nature Immunology in September. Lead authors are Sanjay Garg PhD, postdoctoral fellow, and Joshy Jacob, PhD assistant professor of microbiology and immunology at Emory University School of Medicine and the Yerkes National Primate Research Center. Both are members of the Emory Vaccine Center.
Dendritic cells, the security cameras of the immune system, derive their name from their finger-like projections. They continually capture external proteins, digest the proteins into fragments, and display those fragments on their surfaces. T cells, the police who watch the cameras, have the ability to examine the fragments on the dendritic cells surfaces and sound the alarm to the rest of the immune system if they determine that those fragments are dangerous. Although other kinds of cells also have the ability to present fragments of foreign proteins to the immune system, dendritic cells are the most proficient, and immunologists call them "professional" antigen-presenting cells.
Holly Korschun | EurekAlert!
What happens in the cell nucleus after fertilization
06.12.2016 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
07.12.2016 | Materials Sciences
06.12.2016 | Materials Sciences
06.12.2016 | Medical Engineering