With the full sequence of the human genome now in hand, scientists are turning renewed attention to the molecular processes that regulate the genes encoded by DNA. Estimates are that only a tenth of all genes are expressed at any given time. What controls when and where genes are activated?
Increasingly, researchers believe that the mechanisms that govern gene activity themselves resemble a complicated non-DNA code – an intricate pattern of activity among the molecules that package and control access to the DNA. They suspect that the coordinated interplay of a number of specific enzymes is required to turn on a particular gene.
Now, in a new study using the techniques of structural biology, investigators at The Wistar Institute have shown in detail how two enzymes work together to activate a specific gene by loosening, at that genes location, the compact coils of DNA and packaging proteins called chromatin. The findings bolster the emerging theory that something like a code is responsible for orchestrating genetic activity. A report on the research appears in the August issue of Molecular Cell, published August 28.
Franklin Hoke | EurekAlert!
On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung
New gene catalog of ocean microbiome reveals surprises
18.08.2017 | University of Hawaii at Manoa
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
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