Anyone who made it to high school biology has learned about mitosis, or cell division. One cell divides into two, two into four and so forth in a process designed to pass on exact copies of the DNA in chromosomes to daughter cells. New research, by a University of Georgia team, shows how the genes that control this process are regulated.
The study is important for cancer research because the regulation of cell division goes awry in tumors and normal cell growth and behavior are lost. Understanding how normal cell division is regulated will allow scientists to identify potential targets for cancer therapeutics, said Stephen Dalton, the molecular geneticist who led the UGA team.
"This is fundamental molecular cancer research," Dalton said. "One major problem in cancer is mis-segregation, [when the cells] ability to equally divide chromosomes is lost. One [daughter] cell might get too much genetic information and the other too little.
Kim Carlyle | EurekAlert!
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