Using a new approach for dissecting the complicated interactions among many genes, scientists at Dana-Farber Cancer Institute have discovered how a common cancer gene works in tandem with another gene to spur the unchecked growth of cells. The researchers say the technique was so useful in solving a longstanding puzzle that it may expedite the discovery of other such gene interactions that lead to cancer, and could accelerate the development of new cancer drugs.
The report in the Aug. 8 issue of Cell describes how the method was used in identifying what additional genes are affected by the common oncogene, cyclin D1, when it makes too much of its normal protein. By combining two types of data and applying a powerful statistical tool, the researchers pinpointed an unsuspected gene, C/EBP-beta, as a key mediator of cyclin D1 action.
Justin Lamb, PhD, a molecular biologist at Dana-Farber and lead author of the report, said the previous experimental efforts had failed to identify genetic accomplices of cyclin D1 in triggering cancer. "We didnt know what cyclin D1 was interacting with," said Lamb.
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
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