Professor Lance Lanyon, Principal of The Royal Veterinary College, Karla Lee, Helen Jessop, Rosemary Suswillo, Gul Zaman from the Department of Basic Sciences at The Royal Veterinary College have shown in their research that the Estrogen Receptor has a fundamental role in bone cells by adjusting the bone architecture to match the loads individuals place on them. Their paper is published in the latest edition of Nature.
The strain imposed by mechanical loading on bone tissue normally stimulates a response by bone cells that results in an adjustment to bone architecture and enables the bone to withstand reasonable loads. This research centred on why this process should become less effective in some 50 per cent of post-menopausal women who suffered fractures as a result.
This research shows why estrogen withdrawal results in bone loss – the number of Estrogen Receptors is reduced by the estrogen levels. When estrogen levels decline (as at menopause) ER levels also decline to the extent that they limit the bone cells’ adaptive responses to load bearing thus producing an effective environment of disuse or underuse which permits bone loss.
Virginia Fisher | alfa
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
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