Primary author of several recent studies involving di-n-butyl phthalate (DBP) and linuron (L) discusses his findings and what they mean for understanding human development.
Over the last ten years, US researchers have observed a marked increase in some male reproductive disorders, including undescended testicles, increased instances of testicular cancer, and decreased sperm count. In the last 20 years the rates for testicular cancer have grown almost five-fold in Denmark, yet neighboring Finland has not experienced such a dramatic increase. In an effort to explain this phenomenon, scientists have hypothesized that these human male reproductive deficits may have a common origin: a disturbance in the level of androgen and other critical hormones during fetal development. The results from tests with laboratory animals may help scientists better understand the effect of fetal exposure to certain chemicals has on male reproduction abilities later in life.
Paul M.D. Foster, Ph.D., of the National Institutes of Environmental Sciences, Research Triangle Park, NC, and his colleagues have recently co-authored a series of journal articles examining how fetal exposure to two common environmental agents affects the reproductive capabilities of some laboratory animals. Dr. Foster will be discussing their research during a presentation entitled, "Disruption of Male Reproductive Development by Antiandrogens" during the 55th Annual Meeting of the American Association for Clinical Chemistry (AACC), being held at the Pennsylvania Convention Center, Philadelphia, PA, July 20-24, 2003. More than 16,000 attendees are expected.
Presently, studies of antiandrogen and the male reproductive system are confined to experimental animals, since human studies exposing pregnant women to large quantities of these chemical agents would be inappropriate. Additionally, common human birth defects are difficult to track and definitively establish cause and effect.
Dr. Foster does not believe that the findings of these animal studies should be cause for alarm. While researchers do not know at what dose level exposure to these chemicals might produce effects in humans, they know that in animals, the dose levels that produce the adverse changes are significantly higher than the levels that have been measured in ongoing human studies.
He does believe that this research, and the similar efforts of other research institutions, will expand the effort to determine how environmental and pharmaceutical antiandrogens may impact on human development. The effects of antiandrogen exposure may not be uniform for any population group. This suggests that research in this field should be linked linked to the ongoing effort to map critical developmental signaling pathways that determine why only some react to these selected agents.
Donna Krupa | EurekAlert!
Newly discovered bacteria-binding protein in the intestine
08.12.2016 | University of Gothenburg
The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
08.12.2016 | Materials Sciences
08.12.2016 | Materials Sciences
08.12.2016 | Physics and Astronomy