Link between neuronal calcium channel, mutated gene that causes Huntington’s disease identified

Abnormally high calcium levels spurred on by a mutated gene may lead to the death of neurons associated with Huntington’s disease, an inherited genetic disorder, characterized by mental and physical deterioration, for which there is no known cure.

This discovery by researchers at UT Southwestern Medical Center at Dallas, published in the current issue of Neuron, sheds new light on the process that causes the selective death of neurons in the region of the brain called the striatum. Neurons in this area control emotions, body movements and several other neurological processes, including addiction.

Since the discovery of the huntingtin gene (Htt) in 1993, researchers have been searching for what actually causes certain neurons to die in the striatum, leading to the disease.

“It had not been clear why in Huntington’s only neurons in the striatum are affected,” said Dr. Ilya Bezprozvanny, associate professor of physiology and senior author of the study. “We found that the mutant form of the huntingtin protein causes abnormally high calcium levels in neurons, which likely cause them to die.

“This is the first time that we have some idea about what the mutant huntingtin gene does to kill striatum neurons and opens potentially new areas for treatment of the disease.”

Calcium triggers the release of neurotransmitter signals, a process that initiates communication between neurons in the brain. But too much calcium, Dr. Bezprozvanny said, kills neurons.

Researchers hope the discovery leads to the development of drugs to block the activation of a receptor linked to calcium signaling in striatal neurons, thus potentially slowing the progression of Huntington’s, Dr. Bezprozvanny said. Currently, transgenic mouse models that express the human mutant form of the Htt are being studied.

“We are going to move from biochemical and cellular studies to studies in transgenic mice to test our hypothesis,” he said.

Other UT Southwestern researchers involved in the study include Dr. Anton Maximov, instructor in the Center for Basic Neuroscience; Dr. Tie-Shan Tang, a postdoctoral researcher in physiology and lead author of the study; Dr. Huiping Tu, a postdoctoral researcher in physiology; and Dr. Zhengnan Wang, research associate in physiology. Researchers at the University of British Columbia also contributed.

The study was funded by the National Institutes of Health, the Welch Foundation, the Huntington’s Disease Society of America and the Hereditary Disease Foundation.

Media Contact

Amy Shields EurekAlert!

More Information:

http://www.swmed.edu

All latest news from the category: Life Sciences and Chemistry

Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Back to home

Comments (0)

Write a comment

Newest articles

Lighting up the future

New multidisciplinary research from the University of St Andrews could lead to more efficient televisions, computer screens and lighting. Researchers at the Organic Semiconductor Centre in the School of Physics and…

Researchers crack sugarcane’s complex genetic code

Sweet success: Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants….

Evolution of the most powerful ocean current on Earth

The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica’s ice sheets….

Partners & Sponsors