Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers locate tumor-suppressor gene in fruit flies that controls cell production, death

16.07.2003


UT Southwestern Medical Center at Dallas researchers have discovered a tumor-suppressor gene that, in fruit flies, simultaneously restricts cell proliferation and promotes cell death, a process that may also play an important role in the genesis of cancer in humans.



Removal of the gene, hippo, resulted in tumor formation in every organ of the fruit fly. The findings, which are currently online, will appear in an upcoming issue of Cell.

"This is one of the few genes that has been discovered that directly controls two pathways, cell proliferation and cell apoptosis, or cell death," said Dr. Duojia Pan, assistant professor of physiology and senior author of the study. "Sustained growth of cancer cells requires activation of the cell proliferation machinery and suppression of a system called the apoptotic failsafe mechanism. The combination of suppressed cell death and deregulated cell production is likely a key element in cancer."


The researchers identified hippo by screening the fruit fly, or drosophila, genome for mutations that promoted abnormal tissue growth.

To determine the relationship between hippo and a similar protein found in humans, the researchers replaced the tumor-suppressor gene in fruit flies with a protein in humans called MST2. This resulted in the reduction of tumors in the fruit flies, leading researchers to hypothesize that MST2 plays a similar role in human-tumor suppression.

"We hypothesize that this protein (MST2) may be inactivated in some humans, causing the onset of tumor growth. Tumor suppression is important in humans because it is required to restrict abnormal growth of tissues," said Dr. Pan, the Virginia Murchison Linthicum Scholar in Medical Research.

The researchers report also that hippo is linked to two other tumor-suppressing genes, Salvador and warts.

"These three tumor-suppression genes may define a tumor suppression pathway that coordinately regulates cell proliferation and apoptosis," Dr. Pan said. "This pathway may also be involved in the formation of tumors in mammals."

Current research suggests that the human counterpart of Salvador is mutated in several cancer-cell lines.

"Our findings will stimulate investigations of this tumor suppression pathway in human cancers," Pan added.

By studying fruit flies, scientists have the ability to perform more experiments than in human studies because the fruit fly genome is easily mutated. Fruit flies carry approximately 70 percent of the same disease genes as humans.

Dr. Pan is currently studying three other tumor-suppressor genes, including PTEN, Tuberous Sclerosis 1(TSC1) and Tuberous Sclerosis 2 (TSC2). These genes have previously been identified as tumor-suppressor genes in humans.

Other researchers on the study were Drs. Jixin Dong, Jianbin Huang, and Shian Wu, all postdoctoral researchers in physiology.

The study was supported by the National Institutes of Health, the American Heart Association and the American Cancer Society.


###

Amy Shields | EurekAlert!
Further information:
http://www.swmed.edu/

More articles from Life Sciences:

nachricht Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society

nachricht 127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>