Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Miniature biolab embedded on silicon chip

10.07.2003


Researchers from Cornell University have developed a miniaturized DNA-based biological testing system that fits on a silicon chip and can be customized to detect a wide variety of microorganisms. They present their research today at the American Society for Microbiology’s (ASM) Conference on Bio- Micro- Nano-systems.

The chip consists of two areas. The first area captures the DNA from the sample and purifies it. The second is a reaction chamber where a process called polymerase chain reaction is performed to rapidly replicate the selected segment of DNA, which can then be tested.

"Other people have developed real-time PCR on silicon chips, but nobody has really done the purification of the DNA sample on the same chip," says Nathan Cady, one of the researchers on the study. "As near as we can tell, we are one of the first groups to incorporate the purification step into the chip."



Cady and his colleagues are currently working on incorporating a 3rd step to the process that uses fluorescence technology where an added dye would glow green to, indicate a positive sample.

The chip itself is 2 cm x 4 cm in size. Because PCR requires a precise series of specific temperatures at specific times, it fits into a tiny device (5 cm x 5 cm x 3 cm) that handles the cycling of the temperature. Once they have finally incorporated the fluorescence, Cady expects they will have a device roughly the size of a shoebox that will be capable of real-time automated detection of biological agents.

"Part of the reason we put these functions on a chip is that it simplifies the process," says Cady. "You can hand this to someone in the field, someone who is not a trained lab technician, and they can do it."

Another advantage of this system is that it has a very broad range in what organisms it can be used to detect. That makes it very useful for a variety of purposes from monitoring food and water supplies to detecting agents of biological warfare.

"We can detect pretty much any organism as long as we have the PCR primers for it," says Cady.


The ASM Conference on Bio-, Micro-, Nanosystems, held in collaboration with the IEEE Engineering in Medicine and Biology Society on July 7-10, 2003 at the Plaza Hotel in New York City, is intended to provide an interdisciplinary forum for microbiologists and engineers to explore ways in which microbiology can contribute to the growing field of nanotechnology. For further information on the meeting contact Jim Sliwa, ASM Office of Communications.

Jim Sliwa | EurekAlert!
Further information:
http://www.asmusa.org/

More articles from Life Sciences:

nachricht Show me your leaves - Health check for urban trees
12.12.2017 | Gesellschaft für Ökologie e.V.

nachricht Liver Cancer: Lipid Synthesis Promotes Tumor Formation
12.12.2017 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Long-lived storage of a photonic qubit for worldwide teleportation

12.12.2017 | Physics and Astronomy

Multi-year submarine-canyon study challenges textbook theories about turbidity currents

12.12.2017 | Earth Sciences

Electromagnetic water cloak eliminates drag and wake

12.12.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>