Researchers at the University of Virginia Health System have defined a molecular mechanism by which the activity of low-voltage-activated calcium channels can be decreased. Low-voltage-activated, T-type calcium channels are found in many types of tissue and alterations in their activity can contribute to several pathological conditions, including congestive heart failure, hypertension, cardiac arrhythmias, epilepsy and neuropathic pain. The findings will be published in the July 10 edition of Nature. The team led by Paula Q. Barrett, professor of pharmacology and principle investigator of the study, found that G-protein beta gamma subunits, a class of cell membrane proteins that mediate the actions of hormones within the cell, markedly decrease the flow of calcium through these channels into the cell interior. Because elevation of calcium within cells stimulates cellular activity, regulation of calcium entry is an important way by which the function of cells can be controlled. The research uncovered that only one member of a large family of G-protein subunits binds directly to the calcium channel protein to inhibit channel activity.
"These studies identify the T-type calcium channel as a new target for G-protein beta gamma subunits," Barrett said. "The extraordinary specificity of the interaction between these regulatory molecules could be operative in many types of cells and provides exciting insight into the highly selective ways in which cells work. Knowledge of these interactions will lead to the development of new and more specific drugs in the future."
Abena Foreman-Trice | EurekAlert!
Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel
Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
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