Scientists from Harvard Medical School and the Massachusetts Institute of Technology have developed a strategy that could one day be used to create functional human organs such as kidneys and livers. They present their research today at the American Society for Microbiologys conference on Bio- Micro- Nano-systems.
The technique involves creating a network of microscopic tubes that branch out in a pattern, similar to that seen in the circulatory system, to provide oxygen and nutrients to liver or kidney cells that have been cultured in a lab. Using new fractal computational models, the network is designed and etched onto silicon surfaces which are then used as molds to transfer the pattern to biocompatible polymer films. Two films are then sealed together with a microporous membrane sandwiched between them.
"These technologies create a precise architectural framework for the liver or kidney cells that are responsible for the functional replacement of the vital organs," says Mohammad Kaazempur-Mofrad of MITs department of mechanical engineering and division of biological engineering, lead researcher on the study, whose lab is in charge of designing the networks. Jeffrey Borenstein at Draper Laboratory oversees the microfabrication and polymer processing and the principle director of the entire project is Joseph Vacanti of Massachusetts General Hospital.
Jim Sliwa | EurekAlert!
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences