Independent research groups have uncovered a new class of proteins, called the chaplins, that function like amyloid fibrils to allow reproductive growth in the bacterium Streptomyces coelicolor. Amyloid proteins are most commonly recognized for their role in Alzheimers disease, where they aggregate into insoluble, mesh-like plaques in the brains of Alzheimers patients. This finding reveals an unprecedented role for amyloid-like proteins in Gram-positive bacteria.
S. coelicolor is a soil-dwelling bacterium that, along with its relatives, produces the majority of naturally derived antibiotics (e.g., tetracycline and erythromycin), as well as many antitumor, antifungal, and immunosuppressant agents. Unlike most other prokaryotes, S. coelicolor has a complex life cycle, producing two different cell types depending upon environmental conditions: vegetative substrate hyphae that grow in moist soil, and aerial hyphae that grow in air and give rise to reproductive spores.
As published in the July 15th issue of Genes & Development, independent research carried out by Dr. Marie Elliot, Dr. Mark Buttner and colleagues at the John Innes Centre (UK) and Stanford University (USA), and by Dennis Claessen, Dr. Lubbert Dijkhuizen, Dr. Han Wösten and colleagues at the University of Groningen and the University of Utrecht (Netherlands), have identified the chaplin protein family as essential mediators of aerial S. coelicolor growth. The research in the Netherlands was funded by a grant of the National Programme EET (Economy, Ecology and Technology) to find biological alternatives for the environmentally harmful antifouling compounds used today on ships.
Heather Cosel | EurekAlert!
A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences