Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers identify protein which could help protect against neuro-degenerative conditions

30.05.2003


Protein could be used as a treatment for Alzheimer’s, Parkinson’s, and Huntington’s disease



A team of researchers from Imperial College London, the Charing Cross Hospital and University College London have identified a protein which could be used to protect against neuro-degenerative conditions such as Alzheimer’s, Parkinson’s, Huntington’s, motor neurone diseases and the damage caused by strokes.

According to research published today in The Journal of Biological Chemistry, the researchers discovered that the naturally occurring protein, 27-kDa heat shock protein (HSP27) was able to reduce cell death in the brain.


Professor Jacqueline de Belleroche, senior author on the paper, from Imperial College London and the Charing Cross Hospital, comments: "At present, there is no cure for neuro-degenerative diseases, such as Alzheimer’s and Parkinson’s, but the discovery of the beneficial effects of this protein in the brain may provide us with a way to at least slow down the disease process."

For the experiment, the researchers used transgenic mice, which had high levels of HSP27 throughout the brain, spinal cord and other tissues. This was found to reduce mortality rate and neuronal cell death in the hippocampus, a part of the brain affected by neurological diseases. Similar results were also obtained when HSP27 was injected directly into the brain.

Professor de Belleroche adds: "Although this is unlikely to provide a cure for neuro-degenerative disorders, it could be vital in slowing their progress. Eventually it may be possible to use a drug to increase levels of HSP27 in the brain which could be given to those suffering from neuro-degenerative diseases."

Heat shock proteins (HSPs) are a group of proteins present in all cells in all life forms, and are induced when a cell undergoes environmental stresses such as heat, cold and oxygen deprivation.

They are also present in cells under normal conditions, and act like ’chaperones’ to make sure the cell’s proteins are in the right place and shape at the right time.

Tony Stephenson | EurekAlert!
Further information:
http://www.ic.ac.uk/

More articles from Life Sciences:

nachricht Chains of nanogold – forged with atomic precision
23.09.2016 | Suomen Akatemia (Academy of Finland)

nachricht Self-assembled nanostructures hit their target
23.09.2016 | King Abdullah University of Science and Technology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

Im Focus: Launch of New Industry Working Group for Process Control in Laser Material Processing

At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.

In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...

Im Focus: New laser joining technologies at ‘K 2016’ trade fair

Every three years, the plastics industry gathers at K, the international trade fair for plastics and rubber in Düsseldorf. The Fraunhofer Institute for Laser Technology ILT will also be attending again and presenting many innovative technologies, such as for joining plastics and metals using ultrashort pulse lasers. From October 19 to 26, you can find the Fraunhofer ILT at the joint Fraunhofer booth SC01 in Hall 7.

K is the world’s largest trade fair for the plastics and rubber industry. As in previous years, the organizers are expecting 3,000 exhibitors and more than...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

ICPE in Graz for the seventh time

20.09.2016 | Event News

Using mathematical models to understand our brain

16.09.2016 | Event News

 
Latest News

Chains of nanogold – forged with atomic precision

23.09.2016 | Life Sciences

New leukemia treatment offers hope

23.09.2016 | Health and Medicine

Self-assembled nanostructures hit their target

23.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>