Researchers at Washington University School of Medicine in St. Louis have begun unraveling the network of genes and proteins that regulate the lives of cells. The investigators compared the genome of the yeast Saccharomyces cerevisiae (S. cerevisiae) to those of five other yeast species to identify all the locations at which molecules known as regulatory proteins attach to DNA to turn genes on and off. The study is published in the May 30 issue of the journal Science.
Among the many potential sites of gene regulation, 79 were predicted to be definitive new regulatory sites. The investigators also discovered 43 new genes and determined that 515 suspected genes are not genes at all. The findings revised the estimated number of genes in the S. cerevisiae genome from 6,331 to 5,773.
"This is the first step in understanding the gene-regulation network in a simple cell," says principal investigator Mark Johnston, Ph.D., professor of genetics and interim chair of genetics. "This work also will provide guidelines for analyzing the regulatory network of human cells, which will be a much more complex task."
Darrell E. Ward | EurekAlert!
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The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
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Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
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