Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene that controls susceptibility to tuberculosis discovered

13.05.2003


Investigators at the Research Institute of the McGill University Health Centre (MUHC) have identified a gene that regulates the susceptibility to tuberculosis. This finding is published in this week’s edition of the Proceedings of the National Academy of Sciences.

Tuberculosis, an infectious disease caused by the bacteria Mycobacterium tuberculosis, affects approximately 1.9 billion people worldwide. However, a large proportion of these individuals do not develop tuberculosis symptoms. Their body defense systems, or immune systems, are capable of controlling the growth of the bacteria.

"We have identified a gene that controls Mycobacterium tuberculosis growth in the lung," says MUHC microbiologist and senior author Dr. Philippe Gros. "This is an important step toward understanding why some infected individuals are able to fight off the infection and others are not. This discovery may lead to innovative prevention and treatment strategies for the 2 million patients who die from tuberculosis yearly."



Gros, also a professor of Biochemistry and Medicine at McGill University, along with his graduate student, Loukia Mitsosand, and his colleagues from the University of Oxford and the Trudeau Institute in Saranac Lake NY, used a mouse model and a technique called genome scanning to find the gene. They infected mice with air-borne bacteria and compared the DNA of those who were susceptible to infection with those who were not. A common gene variant on chromosome 19 was identified in those mice that were susceptible to infection. These mice had greater number of bacteria in their lungs and died earlier. "We believe that the gene variant, Trl-4, controls the growth of the bacteria in the lung. The next step is to test if this gene is present in humans who are susceptible to the disease," concludes Gros.


This study, funded by the National Institutes of Health, is available online at http://www.pnas.org.

For more information, please contact:
Christine Zeindler, MSc
Communications Coordinator (Research)
McGill University Health Centre Communications Services
514-934-1934 ext. 36419
pager: 514-406-1577


Christine Zeindler | EurekAlert!
Further information:
http://www.mcgill.ca/
http://www.pnas.org

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>