In studies that could be vital to an expanding field of industrial biotechnology, scientists at the Center for Biosystems Research are learning to censor what E.coli bacteria are ’talking’ about.
Cell-to-cell cross talking by laboratory E. coli strains engineered to produce antibiotics, industrial polymers or other products in fermentation vessels can lead to stress in the culture and severely limit product output. But scientists with CBR and partners have begun to decipher and override stress ’talk’ among cells of recombinant E. coli. CBR is part of the University of Maryland Biotechnology Institute (UMBI).
In separate fermentation experiments with strains of E. coli that produce two important model products--interleukin-2 or organophosphorus hydrolase--the team increased product output by three to four times. The first product is an important drug in preventing cancer and HIV. The latter is a detoxifying agent for biowarfare nerve agents.
Steve Berberich | EurekAlert!
Molecular doorstop could be key to new tuberculosis drugs
20.03.2018 | Rockefeller University
Modified biomaterials self-assemble on temperature cues
20.03.2018 | Duke University
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
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20.03.2018 | Agricultural and Forestry Science
20.03.2018 | Life Sciences
20.03.2018 | Life Sciences