Scientists have finally laid hands on the first member of a recalcitrant group of proteins called the Wnts two decades after their discovery. Important regulators of animal development, these proteins were suspected to have a role in keeping stem cells in their youthful, undifferentiated state - a suspicion that has proven correct, according to research carried out in two laboratories at Stanford University Medical Center. The ability to isolate Wnt proteins could help researchers grow some types of stem cells for use in bone marrow transplants or other therapies.
The gene coding for a protein usually reveals clues about how that protein will react in the lab and how best to isolate it from other molecules. The Wnts are unusual, however, because the way they behave in the lab differs from what the gene suggests. Roeland Nusse, PhD, professor of developmental biology at the School of Medicine and one of the first to isolate a Wnt (pronounced "wint") gene, reports how his lab members overcame these hurdles in the April 27 advance online edition of the journal Nature.
"We found that the protein is modified, explaining why it has been difficult to isolate," said Nusse, who is also an investigator at the Howard Hughes Medical Institute. Although the proteins structure suggests it should dissolve easily in water, Karl Willert, PhD, a postdoctoral fellow in Nusses lab, found that an attached fat molecule makes the protein shun water and prefer the company of detergents instead.
Modern genetic sequencing tools give clearer picture of how corals are related
17.08.2017 | University of Washington
The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
17.08.2017 | Physics and Astronomy
17.08.2017 | Earth Sciences
17.08.2017 | Physics and Astronomy