Dr. Wesley Sundquist, professor of biochemistry at the University of Utah, will present at the Experimental Biology 2003 meeting in San Diego on his work in elucidating how HIV is manufactured and assembled in the cell.
The raison dêtre of a virus such as HIV, if a non-living thing can be said to have one, is to turn a host cell into a factory that churns out virus copies and releases them to infect other cells. Dr. Sundquists research has focused on discovering the mechanisms underlying this manufacturing process.
By identifying and characterizing the structures of specific cellular proteins that are crucial to assembling HIV, Dr. Sundquist is providing potential new targets for future anti-HIV drugs. For example, he and his colleagues were the first to show that a protein called TSG101 is required for HIV release. HIV needs TSG101 in order to escape from its host cell in a process termed budding. Dr. Sundquists team has also determined the structure of the part of TSG101 to which HIV binds. Finding ways to alter this structure or otherwise block its binding to HIV theoretically would prevent budding and slow or halt the infection.
Sarah Goodwin | EurekAlert!
First-of-its-kind chemical oscillator offers new level of molecular control
15.12.2017 | University of Texas at Austin
New technique could make captured carbon more valuable
15.12.2017 | DOE/Idaho National Laboratory
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Life Sciences
15.12.2017 | Life Sciences
15.12.2017 | Physics and Astronomy