Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Discovery of proteins necessary for HIV release suggests possible new therapeutic targets


Dr. Wesley Sundquist, professor of biochemistry at the University of Utah, will present at the Experimental Biology 2003 meeting in San Diego on his work in elucidating how HIV is manufactured and assembled in the cell.

The raison d’être of a virus such as HIV, if a non-living thing can be said to have one, is to turn a host cell into a factory that churns out virus copies and releases them to infect other cells. Dr. Sundquist’s research has focused on discovering the mechanisms underlying this manufacturing process.

By identifying and characterizing the structures of specific cellular proteins that are crucial to assembling HIV, Dr. Sundquist is providing potential new targets for future anti-HIV drugs. For example, he and his colleagues were the first to show that a protein called TSG101 is required for HIV release. HIV needs TSG101 in order to escape from its host cell in a process termed budding. Dr. Sundquist’s team has also determined the structure of the part of TSG101 to which HIV binds. Finding ways to alter this structure or otherwise block its binding to HIV theoretically would prevent budding and slow or halt the infection.

Sundquist is the 2003 recipient of the ASBMB-Amgen Award. Among the research strengths for which Dr. Sundquist has been lauded is his use of a wide palette of experimental techniques to determine the structures of key components in HIV assembly. By incorporating nuclear magnetic resonance imaging, cryogenic electron microscopy, genetic analysis, and other technologies into his lab, he has produced compelling findings that have made him a leader in the field of HIV research and structural biology.

Perhaps more significantly, Dr. Sundquist not only produces vivid descriptions of important molecular structures but also uses his findings to predict the potential effects of manipulating these molecules. Having identified the three-dimensional structures of two proteins, named Matrix and Capsid, which are key components of the HIV assembly line, Dr. Sundquist and his colleagues now aim to understand exactly how these proteins help assemble the virus. Their studies will guide the development of drugs that target those proteins.

Sarah Goodwin | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht Biologists unravel another mystery of what makes DNA go 'loopy'
16.03.2018 | Emory Health Sciences

nachricht Scientists map the portal to the cell's nucleus
16.03.2018 | Rockefeller University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>